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Cellosaurus TI-1 [Human leukemia] (CVCL_L806)

[Text version]
Cell line name TI-1 [Human leukemia]
Accession CVCL_L806
Resource Identification Initiative To cite this cell line use: TI-1 [Human leukemia] (RRID:CVCL_L806)
Comments Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=11871388; PubMed=12592342; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00278.
Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=1611097; DOI=10.1182/blood.V80.1.46.46
Taoka T., Tasaka T., Tanaka T., Irino S., Norman A.W.
Characterization, growth, and differentiation of a human myeloid leukemia cell line, TI-1 cell.
Blood 80:46-52(1992)

PubMed=11871388; DOI=10.1182/blood.V99.5.1874
Rush L.J., Heinonen K., Mrozek K., Wolf B.J., Abdel-Rahman M., Szymanska J., Peltomaki P., Kapadia F., Bloomfield C.D., Caligiuri M.A., Plass C.
Comprehensive cytogenetic and molecular genetic characterization of the TI-1 acute myeloid leukemia cell line reveals cross-contamination with K-562 cell line.
Blood 99:1874-1876(2002)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Biological sample resources BioSample; SAMN03151817
Encyclopedic resources Wikidata; Q54972401
Entry history
Entry creation06-May-2013
Last entry update02-May-2024
Version number24