ID   TI-1 [Human leukemia]
AC   CVCL_L806
DR   BioSample; SAMN03151817
DR   Wikidata; Q54972401
RX   PubMed=1611097;
RX   PubMed=11871388;
RX   PubMed=12592342;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=11871388; PubMed=12592342; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00278.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 10-04-25; Version: 26
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RX   PubMed=11871388; DOI=10.1182/blood.V99.5.1874;
RA   Rush, Laura J.
RA   Heinonen, Kristiina
RA   Mrozek, Krzysztof
RA   Wolf, Bryan J.
RA   Abdel-Rahman, Mohamed
RA   Szymanska, Jadwiga
RA   Peltomaki, Paivi Tuulikki
RA   Kapadia, Fehmida
RA   Bloomfield, Clara Derber
RA   Caligiuri, Michael A.
RA   Plass, Christoph
RT   "Comprehensive cytogenetic and molecular genetic characterization of
RT   the TI-1 acute myeloid leukemia cell line reveals cross-contamination
RT   with K-562 cell line.";
RL   Blood 99:1874-1876(2002).
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler, Hans Gunther
RA   Dirks, Wilhelm Gerhard
RA   Matsuo, Yoshinobu
RA   MacLeod, Roderick A.F.
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=1611097; DOI=10.1182/blood.V80.1.46.46;
RA   Taoka, Teruhisa
RA   Tasaka, Taizo
RA   Tanaka, Terukazu
RA   Irino, Shozo
RA   Norman, Anthony W.
RT   "Characterization, growth, and differentiation of a human myeloid
RT   leukemia cell line, TI-1 cell.";
RL   Blood 80:46-52(1992).
//