• Mutation; VGNC; 54168; KDM6A; Simple; p.Thr986fs (c.2957delC); Zygosity=Homozygous (PubMed=31175136).
  

PubMed=20594083; DOI=10.2460/ajvr.71.7.799
McMahon M.B., Bear M.D., Kulp S.K., Pennell M.L., London C.A.
Biological activity of gemcitabine against canine osteosarcoma cell lines in vitro.
Am. J. Vet. Res. 71:799-808(2010)

PubMed=21621658; DOI=10.1016/j.bone.2011.05.008
Scott M.C., Sarver A.L., Gavin K.J., Thayanithy V., Getzy D.M., Newman R.A., Cutter G.R., Lindblad-Toh K., Kisseberth W.C., Hunter L.E., Subramanian S., Breen M., Modiano J.F.
Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach.
Bone 49:356-367(2011)

PubMed=23311495; DOI=10.1186/1750-1172-8-7
Sarver A.L., Thayanithy V., Scott M.C., Cleton-Jansen A.-M., Hogendoorn P.C.W., Modiano J.F., Subramanian S.
MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.
Orphanet J. Rare Dis. 8:7.1-7.11(2013)

PubMed=23365669; DOI=10.1371/journal.pone.0054464
Wells J.W., Evans C.H., Scott M.C., Rutgen B.C., O'Brien T.D., Modiano J.F., Cvetkovic G., Tepic S.
Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.
PLoS ONE 8:E54464-E54464(2013)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

PubMed=36099278; DOI=10.1371/journal.pone.0274383
Megquier K., Turner-Maier J., Morrill K., Li X., Johnson J., Karlsson E.K., London C.A., Gardner H.L.
The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations.
PLoS ONE 17:E0274383-E0274383(2022)