Cellosaurus logo
expasy logo

Cellosaurus OSCA-08 (CVCL_L405)

[Text version]
Cell line name OSCA-08
Synonyms OSCA-8; OSCA8; OSA8
Accession CVCL_L405
Resource Identification Initiative To cite this cell line use: OSCA-08 (RRID:CVCL_L405)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 21 hours (PubMed=27257868); ~22 hours (Kerafast=EMN001-FP).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976.
Sequence variations
  • Mutation; VGNC; VGNC:54168; KDM6A; Simple; p.Thr986fs (c.2957delC); Zygosity=Homozygous (PubMed=31175136).
Disease Canine osteosarcoma (NCIt: C120045)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Rottweiler; VBO=VBO_0201143.
Sex of cell Male
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Markers:
Dog FHC2010227
Dog FHC2054156
Dog FHC2079271,291
Dog PEZ1107,111
Dog PEZ12295
Dog PEZ20176
Dog PEZ3121,124
Dog PEZ5111
Dog PEZ6179
Dog PEZ8236

Run an STR similarity search on this cell line
Publications

PubMed=20594083; DOI=10.2460/ajvr.71.7.799
Melanie B. McMahon, Misty D. Bear, Samuel Kiyota Kulp, Michael L. Pennell, Cheryl A. London;
Biological activity of gemcitabine against canine osteosarcoma cell lines in vitro.
Am. J. Vet. Res. 71:799-808(2010)

PubMed=21621658; DOI=10.1016/j.bone.2011.05.008; PMCID=PMC3143255
Milcah C. Scott, Aaron L. Sarver, Katherine J. Gavin, Venugopal Thayanithy, David M. Getzy, Robert A. Newman, Gary R. Cutter, Kerstin Lindblad-Toh, William C. Kisseberth, Lawrence E. Hunter, Subbaya Subramanian ...Show all 13 authors... , Matthew Breen, Jaime F. Modiano; Show fewer authors
Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach.
Bone 49:356-367(2011)

PubMed=23311495; DOI=10.1186/1750-1172-8-7; PMCID=PMC3566973
Aaron L. Sarver, Venugopal Thayanithy, Milcah C. Scott, Anne-Marie Cleton-Jansen, Pancras Cornelis Wilhelmus Hogendoorn, Jaime F. Modiano, Subbaya Subramanian;
MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.
Orphanet J. Rare Dis. 8:7.1-7.11(2013)

PubMed=23365669; DOI=10.1371/journal.pone.0054464; PMCID=PMC3554772
James W. Wells, Christopher H. Evans, Milcah C. Scott, Barbara C. Rutgen, Timothy D. O'Brien, Jaime F. Modiano, Goran Cvetkovic, Slobodan Tepic;
Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.
PLoS ONE 8:e54464.1-e54464.9(2013)

PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608
Junko Maeda, Coral Eva Froning, Colleen A. Brents, Barbara J. Rose, Douglas H. Thamm, Takamitsu A. Kato;
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:e0156689.1-e0156689.18(2016)

PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225
Jared S. Fowles, Deanna D. Dailey, Daniel L. Gustafson, Douglas H. Thamm, Dawn L. Duval;
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748
Sunetra Das, Rupa Idate, Kathryn E. Cronise, Daniel L. Gustafson, Dawn L. Duval;
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

PubMed=36099278; DOI=10.1371/journal.pone.0274383; PMCID=PMC9469990
Kate Megquier, Jason Turner-Maier, Kathleen Morrill, Xue Li, Jeremy Johnson, Elinor K. Karlsson, Cheryl A. London, Heather L. Gardner;
The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations.
PLoS ONE 17:e0274383.1-e0274383.18(2022)

Cross-references
Cell line collections (Providers) Kerafast; EMN001-FP
Encyclopedic resources Wikidata; Q54936603
Gene expression databases GEO; GSM1974797
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number24