ID   OSCA-08
AC   CVCL_L405
SY   OSCA-8; OSCA8; OSA8
DR   GEO; GSM1974797
DR   Kerafast; EMN001-FP
DR   Wikidata; Q54936603
RX   PubMed=20594083;
RX   PubMed=21621658;
RX   PubMed=23311495;
RX   PubMed=23365669;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
RX   PubMed=36099278;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 21 hours (PubMed=27257868); ~22 hours (Kerafast=EMN001-FP).
CC   Sequence variation: Mutation; VGNC; 54168; KDM6A; Simple; p.Thr986fs (c.2957delC); Zygosity=Homozygous (PubMed=31175136).
CC   Omics: Deep exome analysis.
CC   Omics: Genome sequenced.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976.
CC   Breed/subspecies: Rottweiler.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 227
ST   Dog FHC2054: 156
ST   Dog FHC2079: 271,291
ST   Dog PEZ1: 107,111
ST   Dog PEZ3: 121,124
ST   Dog PEZ5: 111
ST   Dog PEZ6: 179
ST   Dog PEZ8: 236
ST   Dog PEZ12: 295
ST   Dog PEZ20: 176
DI   NCIt; C120045; Canine osteosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Male
AG   2Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 29-06-23; Version: 21
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RX   PubMed=20594083; DOI=10.2460/ajvr.71.7.799;
RA   McMahon M.B., Bear M.D., Kulp S.K., Pennell M.L., London C.A.;
RT   "Biological activity of gemcitabine against canine osteosarcoma cell
RT   lines in vitro.";
RL   Am. J. Vet. Res. 71:799-808(2010).
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RX   PubMed=21621658; DOI=10.1016/j.bone.2011.05.008;
RA   Scott M.C., Sarver A.L., Gavin K.J., Thayanithy V., Getzy D.M.,
RA   Newman R.A., Cutter G.R., Lindblad-Toh K., Kisseberth W.C.,
RA   Hunter L.E., Subramanian S., Breen M., Modiano J.F.;
RT   "Molecular subtypes of osteosarcoma identified by reducing tumor
RT   heterogeneity through an interspecies comparative approach.";
RL   Bone 49:356-367(2011).
//
RX   PubMed=23311495; DOI=10.1186/1750-1172-8-7;
RA   Sarver A.L., Thayanithy V., Scott M.C., Cleton-Jansen A.-M.,
RA   Hogendoorn P.C.W., Modiano J.F., Subramanian S.;
RT   "MicroRNAs at the human 14q32 locus have prognostic significance in
RT   osteosarcoma.";
RL   Orphanet J. Rare Dis. 8:7.1-7.11(2013).
//
RX   PubMed=23365669; DOI=10.1371/journal.pone.0054464;
RA   Wells J.W., Evans C.H., Scott M.C., Rutgen B.C., O'Brien T.D.,
RA   Modiano J.F., Cvetkovic G., Tepic S.;
RT   "Arginase treatment prevents the recovery of canine lymphoma and
RT   osteosarcoma cells resistant to the toxic effects of prolonged
RT   arginine deprivation.";
RL   PLoS ONE 8:E54464-E54464(2013).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689;
RA   Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.;
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:E0156689-E0156689(2016).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//
RX   PubMed=36099278; DOI=10.1371/journal.pone.0274383;
RA   Megquier K., Turner-Maier J., Morrill K., Li X., Johnson J.,
RA   Karlsson E.K., London C.A., Gardner H.L.;
RT   "The genomic landscape of canine osteosarcoma cell lines reveals
RT   conserved structural complexity and pathway alterations.";
RL   PLoS ONE 17:E0274383-E0274383(2022).
//