| Cell line name |
OS2.4 |
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| Synonyms |
OS2_4 |
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| Accession |
CVCL_L370 |
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| Resource Identification Initiative |
To cite this cell line use: OS2.4 (RRID:CVCL_L370) |
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| Comments |
Part of: FACC canine tumor cell line panel.
Omics: Deep exome analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976. |
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| Sequence variations |
- Mutation; VGNC; 47719; TP53; Simple; p.Ile222Thr (c.665T>C); Zygosity=Homozygous (PubMed=31175136).
|
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| Disease |
Canine osteosarcoma (NCIt: C120045) |
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| Species of origin |
Canis lupus familiaris (Dog) (Canis familiaris)
(NCBI Taxonomy: 9615)
Breed/subspecies: Golden Retriever. |
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| Hierarchy |
Children:
|
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| Sex of cell |
Male |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): PubMed=27197945; PubMed=31175136
Markers:| Dog FHC2010 | 231,239 |
| Dog FHC2054 | 176 |
| Dog FHC2079 | 275 |
| Dog PEZ1 | 119 |
| Dog PEZ12 | 285 |
| Dog PEZ20 | 180 |
| Dog PEZ3 | 121 |
| Dog PEZ5 | 111 |
| Dog PEZ6 | 176,179 |
| Dog PEZ8 | 236,240 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=9585065; DOI=10.1016/S0304-3835(98)00004-4
Mealey K.L., Barhoumi R., Rogers K., Kochevar D.T.
Doxorubicin induced expression of P-glycoprotein in a canine osteosarcoma cell line.
Cancer Lett. 126:187-192(1998) PubMed=21801068; DOI=10.2460/ajvr.72.8.1097
Stokol T., Daddona J.L., Mubayed L.S., Trimpert J., Kang S.
Evaluation of tissue factor expression in canine tumor cells.
Am. J. Vet. Res. 72:1097-1106(2011) PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017) PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019) PubMed=36099278; DOI=10.1371/journal.pone.0274383
Megquier K., Turner-Maier J., Morrill K., Li X., Johnson J., Karlsson E.K., London C.A., Gardner H.L.
The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations.
PLoS ONE 17:E0274383-E0274383(2022) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q54936551
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| Gene expression databases |
GEO; GSM1974796
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| Entry history |
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| Entry creation | 06-May-2013 |
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| Last entry update | 29-Jun-2023 |
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| Version number | 15 |
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