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Cellosaurus OS2.4 (CVCL_L370)

[Text version]
Cell line name OS2.4
Synonyms OS2_4
Accession CVCL_L370
Resource Identification Initiative To cite this cell line use: OS2.4 (RRID:CVCL_L370)
Comments Part of: FACC canine tumor cell line panel.
Omics: Deep exome analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976.
Sequence variations
  • Mutation; VGNC; 47719; TP53; Simple; p.Ile222Thr (c.665T>C); Zygosity=Homozygous (PubMed=31175136).
Disease Canine osteosarcoma (NCIt: C120045)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Golden Retriever.
Hierarchy Children:
CVCL_L371 (OS2.4/Doxo)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Dog FHC2010231,239
Dog FHC2054176
Dog FHC2079275
Dog PEZ1119
Dog PEZ12285
Dog PEZ20180
Dog PEZ3121
Dog PEZ5111
Dog PEZ6176,179
Dog PEZ8236,240

Run an STR similarity search on this cell line

PubMed=9585065; DOI=10.1016/S0304-3835(98)00004-4
Mealey K.L., Barhoumi R., Rogers K., Kochevar D.T.
Doxorubicin induced expression of P-glycoprotein in a canine osteosarcoma cell line.
Cancer Lett. 126:187-192(1998)

PubMed=21801068; DOI=10.2460/ajvr.72.8.1097
Stokol T., Daddona J.L., Mubayed L.S., Trimpert J., Kang S.
Evaluation of tissue factor expression in canine tumor cells.
Am. J. Vet. Res. 72:1097-1106(2011)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

PubMed=36099278; DOI=10.1371/journal.pone.0274383
Megquier K., Turner-Maier J., Morrill K., Li X., Johnson J., Karlsson E.K., London C.A., Gardner H.L.
The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations.
PLoS ONE 17:E0274383-E0274383(2022)

Encyclopedic resources Wikidata; Q54936551
Gene expression databases GEO; GSM1974796
Entry history
Entry creation06-May-2013
Last entry update29-Jun-2023
Version number15