ID   OS2.4
AC   CVCL_L370
SY   OS2_4
DR   GEO; GSM1974796
DR   Wikidata; Q54936551
RX   PubMed=9585065;
RX   PubMed=21801068;
RX   PubMed=27197945;
RX   PubMed=31175136;
RX   PubMed=36099278;
CC   Part of: FACC canine tumor cell line panel.
CC   Sequence variation: Mutation; VGNC; 47719; TP53; Simple; p.Ile222Thr (c.665T>C); Zygosity=Homozygous (PubMed=31175136).
CC   Omics: Deep exome analysis.
CC   Omics: Genome sequenced.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976.
CC   Breed/subspecies: Golden Retriever.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 231,239
ST   Dog FHC2054: 176
ST   Dog FHC2079: 275
ST   Dog PEZ1: 119
ST   Dog PEZ3: 121
ST   Dog PEZ5: 111
ST   Dog PEZ6: 176,179
ST   Dog PEZ8: 236,240
ST   Dog PEZ12: 285
ST   Dog PEZ20: 180
DI   NCIt; C120045; Canine osteosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 29-06-23; Version: 15
//
RX   PubMed=9585065; DOI=10.1016/S0304-3835(98)00004-4;
RA   Mealey K.L., Barhoumi R., Rogers K., Kochevar D.T.;
RT   "Doxorubicin induced expression of P-glycoprotein in a canine
RT   osteosarcoma cell line.";
RL   Cancer Lett. 126:187-192(1998).
//
RX   PubMed=21801068; DOI=10.2460/ajvr.72.8.1097;
RA   Stokol T., Daddona J.L., Mubayed L.S., Trimpert J., Kang S.;
RT   "Evaluation of tissue factor expression in canine tumor cells.";
RL   Am. J. Vet. Res. 72:1097-1106(2011).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//
RX   PubMed=36099278; DOI=10.1371/journal.pone.0274383;
RA   Megquier K., Turner-Maier J., Morrill K., Li X., Johnson J.,
RA   Karlsson E.K., London C.A., Gardner H.L.;
RT   "The genomic landscape of canine osteosarcoma cell lines reveals
RT   conserved structural complexity and pathway alterations.";
RL   PLoS ONE 17:E0274383-E0274383(2022).
//