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Cellosaurus HMPOS (CVCL_L355)

[Text version]
Cell line name HMPOS
Synonyms Highly Metastasizing POS cells
Accession CVCL_L355
Resource Identification Initiative To cite this cell line use: HMPOS (RRID:CVCL_L355)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 20 hours (PubMed=27257868).
Omics: Cell surface proteome.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Bone, left femur; UBERON=UBERON_0000981.
Sequence variations
  • Mutation; VGNC; 47719; TP53; Simple; p.Arg164His (c.491G>A); Zygosity=Homozygous (PubMed=31175136).
Disease Canine osteosarcoma (NCIt: C120045)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Mixed breed.
Hierarchy Parent: CVCL_L413 (POS [Dog osteosarcoma])
Sex of cell Male
Age at sampling 1-2Y
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Dog FHC2010235,239
Dog FHC2054151,156
Dog FHC2079275
Dog PEZ1111,123
Dog PEZ12270,297
Dog PEZ20172,184
Dog PEZ3124,127
Dog PEZ5103,107
Dog PEZ6179
Dog PEZ8232,240

Run an STR similarity search on this cell line

PubMed=10342286; DOI=10.1292/jvms.61.361
Barroga E.F., Kadosawa T., Okumura M., Fujinaga T.
Establishment and characterization of the growth and pulmonary metastasis of a highly lung metastasizing cell line from canine osteosarcoma in nude mice.
J. Vet. Med. Sci. 61:361-367(1999)

PubMed=21801068; DOI=10.2460/ajvr.72.8.1097
Stokol T., Daddona J.L., Mubayed L.S., Trimpert J., Kang S.
Evaluation of tissue factor expression in canine tumor cells.
Am. J. Vet. Res. 72:1097-1106(2011)

PubMed=23758893; DOI=10.1186/1746-6148-9-116
Milovancev M., Hilgart-Martiszus I.F., McNamara M.J., Goodall C.P., Seguin B., Bracha S., Wickramasekara S.I.
Comparative analysis of the surface exposed proteome of two canine osteosarcoma cell lines and normal canine osteoblasts.
BMC Vet. Res. 9:116.1-116.10(2013)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

PubMed=31959767; DOI=10.1038/s41598-019-56878-x
Song Z.-F., Pearce M.C., Jiang Y., Yang L.-P., Goodall C.P., Miranda C.L., Milovancev M., Bracha S., Kolluri S.K., Maier C.S.
Delineation of hypoxia-induced proteome shifts in osteosarcoma cells with different metastatic propensities.
Sci. Rep. 10:727-727(2020)

PubMed=33446089; DOI=10.1177/1040638720985242
Ayers J., Milner R.J., Cortes-Hinojosa G., Riva A., Axiak-Bechtel S.M., Sahay B., Cascio M., Lejeune A., Shiomitsu K., Souza C., Hernandez O., Salute M.E.
Novel application of single-cell next-generation sequencing for determination of intratumoral heterogeneity of canine osteosarcoma cell lines.
J. Vet. Diagn. Invest. 33:261-278(2021)

PubMed=36099278; DOI=10.1371/journal.pone.0274383
Megquier K., Turner-Maier J., Morrill K., Li X., Johnson J., Karlsson E.K., London C.A., Gardner H.L.
The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations.
PLoS ONE 17:E0274383-E0274383(2022)

Anatomy/cell type resources BTO; BTO:0005369
Encyclopedic resources Wikidata; Q54889947
Gene expression databases GEO; GSM1974790
Proteomic databases PRIDE; PXD008986
Entry history
Entry creation06-May-2013
Last entry update29-Jun-2023
Version number18