ID   HMPOS
AC   CVCL_L355
SY   Highly Metastasizing POS cells
DR   BTO; BTO_0005369
DR   GEO; GSM1974790
DR   PRIDE; PXD008986
DR   Wikidata; Q54889947
RX   PubMed=10342286;
RX   PubMed=21801068;
RX   PubMed=23758893;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
RX   PubMed=31959767;
RX   PubMed=33446089;
RX   PubMed=36099278;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 20 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; VGNC:47719; TP53; Simple; p.Arg164His (c.491G>A); Zygosity=Homozygous (PubMed=31175136).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Proteomics; Subcellular; Cell surface.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Bone, left femur; UBERON=UBERON_0000981.
CC   Breed/subspecies: Mixed breed; VBO=VBO_0200902.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 235,239
ST   Dog FHC2054: 151,156
ST   Dog FHC2079: 275
ST   Dog PEZ1: 111,123
ST   Dog PEZ3: 124,127
ST   Dog PEZ5: 103,107
ST   Dog PEZ6: 179
ST   Dog PEZ8: 232,240
ST   Dog PEZ12: 270,297
ST   Dog PEZ20: 172,184
DI   NCIt; C120045; Canine osteosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_L413 ! POS [Dog osteosarcoma]
SX   Male
AG   1-2Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 10-04-25; Version: 21
//
RX   PubMed=33446089; DOI=10.1177/1040638720985242; PMCID=PMC7944434;
RA   Ayers, Jordan
RA   Milner, Rowan J.
RA   Cortes-Hinojosa, Galaxia
RA   Riva, Alberto
RA   Axiak-Bechtel, Sandra M.
RA   Sahay, Bikash
RA   Cascio, Matthew
RA   Lejeune, Amandine
RA   Shiomitsu, Keijiro
RA   Souza, Carlos
RA   Hernandez, Oscar
RA   Salute, Marc E.
RT   "Novel application of single-cell next-generation sequencing for
RT   determination of intratumoral heterogeneity of canine osteosarcoma
RT   cell lines.";
RL   J. Vet. Diagn. Invest. 33:261-278(2021).
//
RX   PubMed=10342286; DOI=10.1292/jvms.61.361;
RA   Barroga, Edward F.
RA   Kadosawa, Tsuyoshi
RA   Okumura, Masahiro
RA   Fujinaga, Toru
RT   "Establishment and characterization of the growth and pulmonary
RT   metastasis of a highly lung metastasizing cell line from canine
RT   osteosarcoma in nude mice.";
RL   J. Vet. Med. Sci. 61:361-367(1999).
//
RX   PubMed=36099278; DOI=10.1371/journal.pone.0274383; PMCID=PMC9469990;
RA   Megquier, Kate
RA   Turner-Maier, Jason
RA   Morrill, Kathleen
RA   Li, Xue
RA   Johnson, Jeremy
RA   Karlsson, Elinor K.
RA   London, Cheryl A.
RA   Gardner, Heather L.
RT   "The genomic landscape of canine osteosarcoma cell lines reveals
RT   conserved structural complexity and pathway alterations.";
RL   PLoS ONE 17:e0274383.1-e0274383.18(2022).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225;
RA   Fowles, Jared S.
RA   Dailey, Deanna D.
RA   Gustafson, Daniel L.
RA   Thamm, Douglas H.
RA   Duval, Dawn L.
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748;
RA   Das, Sunetra
RA   Idate, Rupa
RA   Cronise, Kathryn E.
RA   Gustafson, Daniel L.
RA   Duval, Dawn L.
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole-exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//
RX   PubMed=23758893; DOI=10.1186/1746-6148-9-116; PMCID=PMC3684535;
RA   Milovancev, Milan
RA   Hilgart-Martiszus, Ian Felipe
RA   McNamara, Michael J.
RA   Goodall, Cheri P.
RA   Seguin, Bernard
RA   Bracha, Shay
RA   Wickramasekara, Samanthi I.
RT   "Comparative analysis of the surface exposed proteome of two canine
RT   osteosarcoma cell lines and normal canine osteoblasts.";
RL   BMC Vet. Res. 9:116.1-116.10(2013).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608;
RA   Maeda, Junko
RA   Froning, Coral Eva
RA   Brents, Colleen A.
RA   Rose, Barbara J.
RA   Thamm, Douglas H.
RA   Kato, Takamitsu A.
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:e0156689.1-e0156689.18(2016).
//
RX   PubMed=31959767; DOI=10.1038/s41598-019-56878-x; PMCID=PMC6971036;
RA   Song, Zi-Feng
RA   Pearce, Martin C.
RA   Jiang, Yuan
RA   Yang, Li-Ping
RA   Goodall, Cheri P.
RA   Miranda, Cristobal L.
RA   Milovancev, Milan
RA   Bracha, Shay
RA   Kolluri, Siva K.
RA   Maier, Claudia S.
RT   "Delineation of hypoxia-induced proteome shifts in osteosarcoma cells
RT   with different metastatic propensities.";
RL   Sci. Rep. 10:727.1-727.17(2020).
//
RX   PubMed=21801068; DOI=10.2460/ajvr.72.8.1097;
RA   Stokol, Tracy
RA   Daddona, Janelle L.
RA   Mubayed, Lamya S.
RA   Trimpert, Jakob
RA   Kang, Sungkwon
RT   "Evaluation of tissue factor expression in canine tumor cells.";
RL   Am. J. Vet. Res. 72:1097-1106(2011).
//