AC   CVCL_L355
SY   Highly Metastasizing POS cells
DR   BTO; BTO:0005369
DR   GEO; GSM1974790
DR   PRIDE; PXD008986
DR   Wikidata; Q54889947
RX   PubMed=10342286;
RX   PubMed=21801068;
RX   PubMed=23758893;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
RX   PubMed=31959767;
RX   PubMed=33446089;
RX   PubMed=36099278;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 20 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; 47719; TP53; Simple; p.Arg164His (c.491G>A); Zygosity=Homozygous (PubMed=31175136).
CC   Omics: Cell surface proteome.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Genome sequenced.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Bone, left femur; UBERON=UBERON_0000981.
CC   Breed/subspecies: Mixed breed.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 235,239
ST   Dog FHC2054: 151,156
ST   Dog FHC2079: 275
ST   Dog PEZ1: 111,123
ST   Dog PEZ3: 124,127
ST   Dog PEZ5: 103,107
ST   Dog PEZ6: 179
ST   Dog PEZ8: 232,240
ST   Dog PEZ12: 270,297
ST   Dog PEZ20: 172,184
DI   NCIt; C120045; Canine osteosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_L413 ! POS [Dog osteosarcoma]
SX   Male
AG   1-2Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 29-06-23; Version: 18
RX   PubMed=10342286; DOI=10.1292/jvms.61.361;
RA   Barroga E.F., Kadosawa T., Okumura M., Fujinaga T.;
RT   "Establishment and characterization of the growth and pulmonary
RT   metastasis of a highly lung metastasizing cell line from canine
RT   osteosarcoma in nude mice.";
RL   J. Vet. Med. Sci. 61:361-367(1999).
RX   PubMed=21801068; DOI=10.2460/ajvr.72.8.1097;
RA   Stokol T., Daddona J.L., Mubayed L.S., Trimpert J., Kang S.;
RT   "Evaluation of tissue factor expression in canine tumor cells.";
RL   Am. J. Vet. Res. 72:1097-1106(2011).
RX   PubMed=23758893; DOI=10.1186/1746-6148-9-116;
RA   Milovancev M., Hilgart-Martiszus I.F., McNamara M.J., Goodall C.P.,
RA   Seguin B., Bracha S., Wickramasekara S.I.;
RT   "Comparative analysis of the surface exposed proteome of two canine
RT   osteosarcoma cell lines and normal canine osteoblasts.";
RL   BMC Vet. Res. 9:116.1-116.10(2013).
RX   PubMed=27197945; DOI=10.1111/vco.12192;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689;
RA   Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.;
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:E0156689-E0156689(2016).
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
RX   PubMed=31959767; DOI=10.1038/s41598-019-56878-x;
RA   Song Z.-F., Pearce M.C., Jiang Y., Yang L.-P., Goodall C.P., Miranda C.L.,
RA   Milovancev M., Bracha S., Kolluri S.K., Maier C.S.;
RT   "Delineation of hypoxia-induced proteome shifts in osteosarcoma cells
RT   with different metastatic propensities.";
RL   Sci. Rep. 10:727-727(2020).
RX   PubMed=33446089; DOI=10.1177/1040638720985242;
RA   Ayers J., Milner R.J., Cortes-Hinojosa G., Riva A., Axiak-Bechtel S.M.,
RA   Sahay B., Cascio M., Lejeune A., Shiomitsu K., Souza C., Hernandez O.,
RA   Salute M.E.;
RT   "Novel application of single-cell next-generation sequencing for
RT   determination of intratumoral heterogeneity of canine osteosarcoma
RT   cell lines.";
RL   J. Vet. Diagn. Invest. 33:261-278(2021).
RX   PubMed=36099278; DOI=10.1371/journal.pone.0274383;
RA   Megquier K., Turner-Maier J., Morrill K., Li X., Johnson J.,
RA   Karlsson E.K., London C.A., Gardner H.L.;
RT   "The genomic landscape of canine osteosarcoma cell lines reveals
RT   conserved structural complexity and pathway alterations.";
RL   PLoS ONE 17:E0274383-E0274383(2022).