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Cellosaurus CMT12 (CVCL_L329)

[Text version]
Cell line name CMT12
Synonyms CMT-12; Canine Mammary Tumor 12; CMT-2; CMT2; Canine Mammary Tumor-2
Accession CVCL_L329
Secondary accession CVCL_X219
Resource Identification Initiative To cite this cell line use: CMT12 (RRID:CVCL_L329)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: ~24 hours (PubMed=3462415); 19 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Caution: CMT-2 was renamed CMT-12 in PubMed=11848473.
Caution: On the basis of STR profile (PubMed=21908323; PubMed=27197945) CMT12 and CMT27 seem to originate from the same donor.
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Sequence variations
  • Mutation; VGNC; 42490; KMT2C; Simple; p.Arg1201fs (c.3600delGinsAA); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; 47719; TP53; Simple; p.Val132Glu (c.395T>A); Zygosity=Homozygous (PubMed=31175136).
Disease Canine mammary carcinoma (NCIt: C124249)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Poodle.
Hierarchy Children:
CVCL_C1IG (CMT-12CnB7-1R25)CVCL_C1IH (CMT-12CnB7-1R26)CVCL_C1II (CMT-12CnB7-2Q2)
CVCL_C1IJ (CMT-12HuB7-2C10)CVCL_C1H3 (CMT-2 c1)CVCL_C1H4 (CMT-2 c2)
CVCL_C1H5 (CMT-2 c3)CVCL_C1H6 (CMT-2 c4)CVCL_C1H7 (CMT-2 c5)
Originate from same individual CVCL_1R41 ! CMT27
Sex of cell Female
Age at sampling >10Y
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Dog FHC2010235
Dog FHC2054151,176
Dog FHC2079271
Dog PEZ1115
Dog PEZ12277
Dog PEZ20176
Dog PEZ3113,119
Dog PEZ5103
Dog PEZ6176
Dog PEZ8233,244

Run an STR similarity search on this cell line

PubMed=3462415; DOI=10.1093/jnci/77.3.783
Wolfe L.G., Smith B.B., Toivio-Kinnucan M.A., Sartin E.A., Kwapien R.P., Henderson R.A., Barnes S.
Biologic properties of cell lines derived from canine mammary carcinomas.
J. Natl. Cancer Inst. 77:783-792(1986)

Sartin E.A.
Biological properties of canine mammary tumors and cell lines.
Thesis PhD (1990), Auburn University College of Veterinary Medicine, United States

Sartin E.A., Barnes S., Toivio-Kinnucan M., Wright J.C., Wolfe L.G.
Heterogenic properties of clonal cell lines derived from canine mammary carcinomas and sensitivity to tamoxifen and doxorubicin.
Anticancer Res. 13:229-236(1993)

Vatne V., Litlekalsoey J., Thorsen F., Ness G.O., Wentzel-Larsen T., Hostmark J.G.
Characterization of cell lines originating from an invasive transitional cell carcinoma.
Anticancer Res. 21:3199-3207(2001)

Whitley E.M., Sellins K.S., Ewald S.J., Smith B.F., Yang S.-M., Sartin E.A., Wolfe L.G.
Canine mammary tumor cells transfected with B7-1 or B7-2 stimulate proliferation of peripheral blood mononuclear cells.
Anticancer Res. 22:2567-2574(2002)

PubMed=19130492; DOI=10.1002/jcb.22034
DeInnocentes P., Agarwal P., Bird R.C.
Phenotype-rescue of cyclin-dependent kinase inhibitor p16/INK4A defects in a spontaneous canine cell model of breast cancer.
J. Cell. Biochem. 106:491-505(2009)

PubMed=21801068; DOI=10.2460/ajvr.72.8.1097
Stokol T., Daddona J.L., Mubayed L.S., Trimpert J., Kang S.
Evaluation of tissue factor expression in canine tumor cells.
Am. J. Vet. Res. 72:1097-1106(2011)

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=23238983; DOI=10.1002/jcb.24476
Agarwal P., Sandey M., DeInnocentes P., Bird R.C.
Tumor suppressor gene p16/INK4A/CDKN2A-dependent regulation into and out of the cell cycle in a spontaneous canine model of breast cancer.
J. Cell. Biochem. 114:1355-1363(2013)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Encyclopedic resources Wikidata; Q54813839
Gene expression databases GEO; GSM1974783
Entry history
Entry creation06-May-2013
Last entry update29-Jun-2023
Version number18