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Cellosaurus Abrams (CVCL_L309)

[Text version]
Cell line name Abrams
Synonyms OSA-Abrams
Accession CVCL_L309
Resource Identification Initiative To cite this cell line use: Abrams (RRID:CVCL_L309)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 27.2 hours (PubMed=22916246); 19 hours (PubMed=27257868); 18.72 hours (PubMed=31640712).
Omics: Deep exome analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; VGNC; 47719; TP53; Simple; p.Cys267Phe (c.800G>T); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine osteosarcoma (NCIt: C120045)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Rottweiler.
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Dog FHC2010227,235
Dog FHC2054160,176
Dog FHC2079287,291
Dog PEZ1107,119
Dog PEZ12274,301
Dog PEZ20176
Dog PEZ3121
Dog PEZ5103
Dog PEZ6179,187
Dog PEZ8228,236

Run an STR similarity search on this cell line

PubMed=21552385; DOI=10.7150/jca.2.262
Legare M.E., Bush J., Ashley A.K., Kato T., Hanneman W.H.
Cellular and phenotypic characterization of canine osteosarcoma cell lines.
J. Cancer 2:262-270(2011)

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=22849686; DOI=10.2460/ajvr.73.8.1252
Urbasic A.S., Hynes S., Somrak A.J., Contakos S., Rahman M.M., Liu J., MacNeill A.L.
Oncolysis of canine tumor cells by myxoma virus lacking the serp2 gene.
Am. J. Vet. Res. 73:1252-1261(2012)

PubMed=22916246; DOI=10.1371/journal.pone.0043355
Maeda J., Yurkon C.R., Fujisawa H., Kaneko M., Genet S.C., Roybal E.J., Rota G.W., Saffer E.R., Rose B.J., Hanneman W.H., Thamm D.H., Kato T.A.
Genomic instability and telomere fusion of canine osteosarcoma cells.
PLoS ONE 7:E43355-E43355(2012)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=26842912; DOI=10.1111/vco.12197
Hartley G., Faulhaber E., Caldwell A., Coy J., Kurihara J., Guth A., Regan D., Dow S.
Immune regulation of canine tumour and macrophage PD-L1 expression.
Vet. Comp. Oncol. 15:534-549(2017)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

PubMed=31640712; DOI=10.1186/s12917-019-2099-y
Wilson-Robles H.M., Franks K., Pool R., Miller T.
Characterization of five newly derived canine osteosarcoma cell lines.
BMC Vet. Res. 15:357.1-357.14(2019)

PubMed=36099278; DOI=10.1371/journal.pone.0274383
Megquier K., Turner-Maier J., Morrill K., Li X., Johnson J., Karlsson E.K., London C.A., Gardner H.L.
The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations.
PLoS ONE 17:E0274383-E0274383(2022)

Anatomy/cell type resources BTO; BTO:0005353
Encyclopedic resources Wikidata; Q54607756
Gene expression databases GEO; GSM1974775
Entry history
Entry creation06-May-2013
Last entry update29-Jun-2023
Version number18