ID   Abrams
AC   CVCL_L309
SY   OSA-Abrams
DR   BTO; BTO_0005353
DR   GEO; GSM1974775
DR   Wikidata; Q54607756
RX   PubMed=21552385;
RX   PubMed=21908323;
RX   PubMed=22849686;
RX   PubMed=22916246;
RX   PubMed=26842912;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
RX   PubMed=31640712;
RX   PubMed=36099278;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 27.2 hours (PubMed=22916246); 19 hours (PubMed=27257868); 18.72 hours (PubMed=31640712).
CC   Sequence variation: Mutation; VGNC; VGNC:47719; TP53; Simple; p.Cys267Phe (c.800G>T); Zygosity=Heterozygous (PubMed=31175136).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Bone; UBERON=UBERON_0002481.
CC   Breed/subspecies: Rottweiler; VBO=VBO_0201143.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 227,235
ST   Dog FHC2054: 160,176
ST   Dog FHC2079: 287,291
ST   Dog PEZ1: 107,119
ST   Dog PEZ3: 121
ST   Dog PEZ5: 103
ST   Dog PEZ6: 179,187
ST   Dog PEZ8: 228,236
ST   Dog PEZ12: 274,301
ST   Dog PEZ20: 176
DI   NCIt; C120045; Canine osteosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 10-04-25; Version: 21
//
RX   PubMed=21552385; DOI=10.7150/jca.2.262; PMCID=PMC3088864;
RA   Legare M.E., Bush J., Ashley A.K., Kato T., Hanneman W.H.;
RT   "Cellular and phenotypic characterization of canine osteosarcoma cell
RT   lines.";
RL   J. Cancer 2:262-270(2011).
//
RX   PubMed=21908323; DOI=10.1177/1040638711408064;
RA   O'Donoghue L.E., Rivest J.P., Duval D.L.;
RT   "Polymerase chain reaction-based species verification and
RT   microsatellite analysis for canine cell line validation.";
RL   J. Vet. Diagn. Invest. 23:780-785(2011).
//
RX   PubMed=22849686; DOI=10.2460/ajvr.73.8.1252;
RA   Urbasic A.S., Hynes S., Somrak A.J., Contakos S., Rahman M.M., Liu J.,
RA   MacNeill A.L.;
RT   "Oncolysis of canine tumor cells by myxoma virus lacking the serp2
RT   gene.";
RL   Am. J. Vet. Res. 73:1252-1261(2012).
//
RX   PubMed=22916246; DOI=10.1371/journal.pone.0043355; PMCID=PMC3420908;
RA   Maeda J., Yurkon C.R., Fujisawa H., Kaneko M., Genet S.C.,
RA   Roybal E.J., Rota G.W., Saffer E.R., Rose B.J., Hanneman W.H.,
RA   Thamm D.H., Kato T.A.;
RT   "Genomic instability and telomere fusion of canine osteosarcoma
RT   cells.";
RL   PLoS ONE 7:e43355.1-e43355.12(2012).
//
RX   PubMed=26842912; DOI=10.1111/vco.12197;
RA   Hartley G., Faulhaber E.A., Caldwell A., Coy J., Kurihara J.N.,
RA   Guth A., Regan D.P., Dow S.W.;
RT   "Immune regulation of canine tumour and macrophage PD-L1 expression.";
RL   Vet. Comp. Oncol. 15:534-549(2017).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608;
RA   Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.;
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:e0156689.1-e0156689.18(2016).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole-exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//
RX   PubMed=31640712; DOI=10.1186/s12917-019-2099-y; PMCID=PMC6805340;
RA   Wilson-Robles H.M., Franks K., Pool R., Miller T.;
RT   "Characterization of five newly derived canine osteosarcoma cell
RT   lines.";
RL   BMC Vet. Res. 15:357.1-357.14(2019).
//
RX   PubMed=36099278; DOI=10.1371/journal.pone.0274383; PMCID=PMC9469990;
RA   Megquier K., Turner-Maier J., Morrill K., Li X., Johnson J.,
RA   Karlsson E.K., London C.A., Gardner H.L.;
RT   "The genomic landscape of canine osteosarcoma cell lines reveals
RT   conserved structural complexity and pathway alterations.";
RL   PLoS ONE 17:e0274383.1-e0274383.18(2022).
//