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Cellosaurus OKF4 (CVCL_L220)

[Text version]
Cell line name OKF4
Synonyms OK-F4
Accession CVCL_L220
Resource Identification Initiative To cite this cell line use: OKF4 (RRID:CVCL_L220)
Comments Senescence: Senesces at ~32-37 PDL (PubMed=10648628; PubMed=12077343).
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_L226 (OKF4/E6E7)CVCL_L227 (OKF4/TERT-1)
Originate from same individual CVCL_L219 ! OKB2
CVCL_L221 ! OKP4
Sex of cell Male
Age at sampling 28Y
Category Finite cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=1708735; DOI=10.1111/j.1432-0436.1990.tb00477.x
Kristina Lindberg, James George Rheinwald;
Three distinct keratinocyte subtypes identified in human oral epithelium by their patterns of keratin expression in culture and in xenografts.
Differentiation 45:230-241(1990)

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Mark A. Dickson, William Chun Hahn, Yasushi Ino, Vincent Ronfard, Jenny Y. Wu, Robert Allan Weinberg, David Neil Louis, Frederick Pei Li, James George Rheinwald;
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780
James George Rheinwald, William Chun Hahn, Matthew Robert Ramsey, Jenny Y. Wu, Zong-You Guo, Hensin Tsao, Michele De Luca, Caterina Catricala, Kathleen M. O'Toole;
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

PubMed=25169794; DOI=10.1111/jop.12236
Christopher T.D. Dickman, Rebecca Towle, Rajan Saini, Cathie Garnis;
Molecular characterization of immortalized normal and dysplastic oral cell lines.
J. Oral Pathol. Med. 44:329-336(2015)

Cross-references
Encyclopedic resources Wikidata; Q54931917
Gene expression databases GEO; GSM1431137
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number13