ID   OKF4
AC   CVCL_L220
SY   OK-F4
DR   GEO; GSM1431137
DR   Wikidata; Q54931917
RX   PubMed=1708735;
RX   PubMed=10648628;
RX   PubMed=12077343;
RX   PubMed=25169794;
WW   Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
CC   Senescence: Senesces at ~32-37 PDL (PubMed=10648628; PubMed=12077343).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; CNV analysis.
CC   Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_L219 ! OKB2
OI   CVCL_L221 ! OKP4
SX   Male
AG   28Y
CA   Finite cell line
DT   Created: 06-05-13; Last updated: 10-04-25; Version: 13
//
RX   PubMed=1708735; DOI=10.1111/j.1432-0436.1990.tb00477.x;
RA   Lindberg K., Rheinwald J.G.;
RT   "Three distinct keratinocyte subtypes identified in human oral
RT   epithelium by their patterns of keratin expression in culture and in
RT   xenografts.";
RL   Differentiation 45:230-241(1990).
//
RX   PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304;
RA   Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A.,
RA   Louis D.N., Li F.P., Rheinwald J.G.;
RT   "Human keratinocytes that express hTERT and also bypass a
RT   p16(INK4a)-enforced mechanism that limits life span become immortal yet
RT   retain normal growth and differentiation characteristics.";
RL   Mol. Cell. Biol. 20:1436-1447(2000).
//
RX   PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780;
RA   Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z.-Y., Tsao H.,
RA   De Luca M., Catricala C., O'Toole K.M.;
RT   "A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence
RT   mechanism that limits replicative potential independent of telomere
RT   status.";
RL   Mol. Cell. Biol. 22:5157-5172(2002).
//
RX   PubMed=25169794; DOI=10.1111/jop.12236;
RA   Dickman C.T.D., Towle R., Saini R., Garnis C.;
RT   "Molecular characterization of immortalized normal and dysplastic oral
RT   cell lines.";
RL   J. Oral Pathol. Med. 44:329-336(2015).
//