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Cellosaurus CellSensor DBE-bla MDA-MB-468 (CVCL_KS13)

[Text version]
Cell line name CellSensor DBE-bla MDA-MB-468
Synonyms DBE-bla MDA-MB-468
Accession CVCL_KS13
Resource Identification Initiative To cite this cell line use: CellSensor DBE-bla MDA-MB-468 (RRID:CVCL_KS13)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: African American.
Characteristics: Transfected with a plasmid containing a beta-lactamase reporter gene under control of a FOXO-responsive DBE response element (DBE).
Transfected with: UniProtKB; P62593; Escherichia coli beta-lactamase bla (with p.Met1_Phe22del, p.Ala23Met, p.Val82Ile and p.Met184Val).
Discontinued: Thermofisher/Invitrogen; Catalog number K1814.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0419 (MDA-MB-468)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_KS13
Encyclopedic resources Wikidata; Q54809177
Entry history
Entry creation22-Aug-2017
Last entry update05-Oct-2023
Version number16