ID   CellSensor DBE-bla MDA-MB-468
AC   CVCL_KS13
SY   DBE-bla MDA-MB-468
DR   cancercelllines; CVCL_KS13
DR   Wikidata; Q54809177
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: African American.
CC   Characteristics: Transfected with a plasmid containing a beta-lactamase reporter gene under control of a FOXO-responsive DBE response element (DBE).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P62593; Escherichia coli beta-lactamase bla (Note=With p.Met1_Phe22del, p.Ala23Met, p.Val82Ile and p.Met184Val).
CC   Discontinued: Thermo Fisher/Invitrogen; Catalog number K1814.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0419 ! MDA-MB-468
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 10-04-25; Version: 19
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