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Cellosaurus Kasumi-1 PR48 (CVCL_JY45)

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Cell line name Kasumi-1 PR48
Synonyms PR48
Accession CVCL_JY45
Resource Identification Initiative To cite this cell line use: Kasumi-1 PR48 (RRID:CVCL_JY45)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_49375; Dasatinib (BMS-354825).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:10471; RUNX1 + HGNC; HGNC:1535; RUNX1T1; Name(s)=RUNX1-RUNX1T1, AML1-ETO (from parent cell line).
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Asn822Lys (c.2466T>A) (N818K); ClinVar=VCV000375931; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9811; RAD21; Simple; p.Lys330Profs*6 (c.987insCCGG); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Childhood acute myeloid leukemia with maturation (NCIt: C9381)
Acute myeloblastic leukemia with maturation (ORDO: Orphanet_98834)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_JY44 (Kasumi-1 R48)
Sex of cell Male
Age at sampling 7Y
Category Cancer cell line
Publications

PubMed=24211243; DOI=10.1016/j.exphem.2013.10.006
Markus D. Herrmann, Jochen K. Lennerz, Lars Bullinger, Stephan Bartholomae, Karlheinz Holzmann, Mike-Andrew Westhoff, Selim Corbacioglu, Klaus-Michael Debatin;
Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression.
Exp. Hematol. 42:90-100(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_JY45
Encyclopedic resources Wikidata; Q54899513
Gene expression databases GEO; GSM955195
GEO; GSM955196
GEO; GSM955197
Entry history
Entry creation22-Aug-2017
Last entry update10-Apr-2025
Version number15