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Cellosaurus HepG2-hNTCP (CVCL_JY40)

[Text version]
Cell line name HepG2-hNTCP
Accession CVCL_JY40
Resource Identification Initiative To cite this cell line use: HepG2-hNTCP (RRID:CVCL_JY40)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:10905; SLC10A1.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=24361467; DOI=10.1053/j.gastro.2013.12.024
Yi Ni, Florian A. Lempp, Stefan Mehrle, Shirin Nkongolo, Christina Kaufman, Maria Falth Savitski, Jan Stindt, Christian Koniger, Michael Nassal, Ralf Kubitz, Holger Sultmann, Stephan Urban;
Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes.
Gastroenterology 146:1070-1083(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_JY40
Encyclopedic resources Wikidata; Q54882852
Entry history
Entry creation22-Aug-2017
Last entry update14-Aug-2025
Version number16