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Cellosaurus K562-AVB3 (CVCL_JX91)

[Text version]
Cell line name K562-AVB3
Synonyms K562-avb3; K562 aVb3; K562-alphaVbeta3; avb3-K562; alphaVbeta3-K562
Accession CVCL_JX91
Resource Identification Initiative To cite this cell line use: K562-AVB3 (RRID:CVCL_JX91)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6150; ITGAV.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6156; ITGB3.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=7525603; DOI=10.1083/jcb.127.4.1129; PMCID=PMC2200054
Scott D. Blystone, Irene L. Graham, Frederik P. Lindberg, Eric J. Brown;
Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.
J. Cell Biol. 127:1129-1137(1994)

Cross-references
Encyclopedic resources Wikidata; Q54899379
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number15