ID   K562-AVB3
AC   CVCL_JX91
SY   K562-avb3; K562 aVb3; K562-alphaVbeta3; avb3-K562; alphaVbeta3-K562
DR   Wikidata; Q54899379
RX   PubMed=7525603;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6150; ITGAV.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6156; ITGB3.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 19-12-24; Version: 15
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RX   PubMed=7525603; DOI=10.1083/jcb.127.4.1129; PMCID=PMC2200054;
RA   Blystone S.D., Graham I.L., Lindberg F.P., Brown E.J.;
RT   "Integrin alpha v beta 3 differentially regulates adhesive and
RT   phagocytic functions of the fibronectin receptor alpha 5 beta 1.";
RL   J. Cell Biol. 127:1129-1137(1994).
//