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Cellosaurus HeLa/SN100 (CVCL_JQ54)

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Cell line name HeLa/SN100
Synonyms HeLa:SN100
Accession CVCL_JQ54
Resource Identification Initiative To cite this cell line use: HeLa/SN100 (RRID:CVCL_JQ54)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_JQ53 (HeLa/SN10)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=19201079; DOI=10.1016/j.canlet.2008.12.033
Kohji Takara, Noriaki Kitada, Eri Yoshikawa, Kazuhiro Yamamoto, Sayo Horibe, Toshiyuki Sakaeda, Kohshi Nishiguchi, Noriaki Ohnishi, Teruyoshi Yokoyama;
Molecular changes to HeLa cells on continuous exposure to SN-38, an active metabolite of irinotecan hydrochloride.
Cancer Lett. 278:88-96(2009)

PubMed=22200670; DOI=10.3892/mmr.2011.734
Kohji Takara, Mika Matsubara, Kazuhiro Yamamoto, Tetsuya Minegaki, Shigehiko Takegami, Minoru Takahashi, Teruyoshi Yokoyama, Katsuhiko Okumura;
Differential effects of calcium antagonists on ABCG2/BCRP-mediated drug resistance and transport in SN-38-resistant HeLa cells.
Mol. Med. Rep. 5:603-609(2012)

PubMed=26235782; DOI=10.1038/ncomms8928; PMCID=PMC4532879
Juan D. Chavez, Devin Karl Schweppe, Jimmy K. Eng, Chun-Xiang Zheng, Alexandra Taipale, Yi-Yi Zhang, Kohji Takara, James E. Bruce;
Quantitative interactome analysis reveals a chemoresistant edgotype.
Nat. Commun. 6:7928.1-7928.12(2015)

Cross-references
Encyclopedic resources Wikidata; Q54882703
Proteomic databases PRIDE; PXD002378
Entry history
Entry creation22-Aug-2017
Last entry update10-Apr-2025
Version number9