Cellosaurus cell line HeLa/SN100 (CVCL

Cellosaurus HeLa/SN100 (CVCL_JQ54)

Cross-references
Cell line name	HeLa/SN100
Synonyms	HeLa:SN100
Accession	CVCL_JQ54
Resource Identification Initiative	To cite this cell line use: HeLa/SN100 (RRID:CVCL_JQ54)
Comments	Population: African American. Selected for resistance to: ChEBI; CHEBI_8988; SN-38 (7-ethyl-10-hydroxy-camptothecin). Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease	Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_JQ53 (HeLa/SN10)
Sex of cell	Female
Age at sampling	30Y6M
Category	Cancer cell line
Publications	PubMed=19201079; DOI=10.1016/j.canlet.2008.12.033 Kohji Takara, Noriaki Kitada, Eri Yoshikawa, Kazuhiro Yamamoto, Sayo Horibe, Toshiyuki Sakaeda, Kohshi Nishiguchi, Noriaki Ohnishi, Teruyoshi Yokoyama; Molecular changes to HeLa cells on continuous exposure to SN-38, an active metabolite of irinotecan hydrochloride. Cancer Lett. 278:88-96(2009) PubMed=22200670; DOI=10.3892/mmr.2011.734 Kohji Takara, Mika Matsubara, Kazuhiro Yamamoto, Tetsuya Minegaki, Shigehiko Takegami, Minoru Takahashi, Teruyoshi Yokoyama, Katsuhiko Okumura; Differential effects of calcium antagonists on ABCG2/BCRP-mediated drug resistance and transport in SN-38-resistant HeLa cells. Mol. Med. Rep. 5:603-609(2012) PubMed=26235782; DOI=10.1038/ncomms8928; PMCID=PMC4532879 Juan D. Chavez, Devin K. Schweppe, Jimmy K. Eng, Chun-Xiang Zheng, Alex Taipale, Yi-Yi Zhang, Kohji Takara, James E. Bruce; Quantitative interactome analysis reveals a chemoresistant edgotype. Nat. Commun. 6:7928.1-7928.12(2015)
Encyclopedic resources	Wikidata; Q54882703
Proteomic databases	PRIDE; PXD002378
Entry history
Entry creation	22-Aug-2017
Last entry update	10-Apr-2025
Version number	9