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Cellosaurus HeLa/SN100 (CVCL_JQ54)

[Text version]
Cell line name HeLa/SN100
Synonyms HeLa:SN100
Accession CVCL_JQ54
Resource Identification Initiative To cite this cell line use: HeLa/SN100 (RRID:CVCL_JQ54)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_JQ53 (HeLa/SN10)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=19201079; DOI=10.1016/j.canlet.2008.12.033
Takara K., Kitada N., Yoshikawa E., Yamamoto K., Horibe S., Sakaeda T., Nishiguchi K., Ohnishi N., Yokoyama T.
Molecular changes to HeLa cells on continuous exposure to SN-38, an active metabolite of irinotecan hydrochloride.
Cancer Lett. 278:88-96(2009)

PubMed=22200670; DOI=10.3892/mmr.2011.734
Takara K., Matsubara M., Yamamoto K., Minegaki T., Takegami S., Takahashi M., Yokoyama T., Okumura K.
Differential effects of calcium antagonists on ABCG2/BCRP-mediated drug resistance and transport in SN-38-resistant HeLa cells.
Mol. Med. Rep. 5:603-609(2012)

PubMed=26235782; DOI=10.1038/ncomms8928
Chavez J.D., Schweppe D.K., Eng J.K., Zheng C.-X., Taipale A., Zhang Y.-Y., Takara K., Bruce J.E.
Quantitative interactome analysis reveals a chemoresistant edgotype.
Nat. Commun. 6:7928.1-7928.12(2015)

Cross-references
Encyclopedic resources Wikidata; Q54882703
Proteomic databases PRIDE; PXD002378
Entry history
Entry creation22-Aug-2017
Last entry update05-Oct-2023
Version number7