ID   HeLa/SN100
AC   CVCL_JQ54
SY   HeLa:SN100
DR   PRIDE; PXD002378
DR   Wikidata; Q54882703
RX   PubMed=19201079;
RX   PubMed=22200670;
RX   PubMed=26235782;
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI:8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_JQ53 ! HeLa/SN10
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 05-10-23; Version: 7
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RX   PubMed=19201079; DOI=10.1016/j.canlet.2008.12.033;
RA   Takara K., Kitada N., Yoshikawa E., Yamamoto K., Horibe S.,
RA   Sakaeda T., Nishiguchi K., Ohnishi N., Yokoyama T.;
RT   "Molecular changes to HeLa cells on continuous exposure to SN-38, an
RT   active metabolite of irinotecan hydrochloride.";
RL   Cancer Lett. 278:88-96(2009).
//
RX   PubMed=22200670; DOI=10.3892/mmr.2011.734;
RA   Takara K., Matsubara M., Yamamoto K., Minegaki T., Takegami S.,
RA   Takahashi M., Yokoyama T., Okumura K.;
RT   "Differential effects of calcium antagonists on ABCG2/BCRP-mediated
RT   drug resistance and transport in SN-38-resistant HeLa cells.";
RL   Mol. Med. Rep. 5:603-609(2012).
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RX   PubMed=26235782; DOI=10.1038/ncomms8928;
RA   Chavez J.D., Schweppe D.K., Eng J.K., Zheng C.-X., Taipale A.,
RA   Zhang Y.-Y., Takara K., Bruce J.E.;
RT   "Quantitative interactome analysis reveals a chemoresistant
RT   edgotype.";
RL   Nat. Commun. 6:7928.1-7928.12(2015).
//