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Cellosaurus TIN2 F/F (CVCL_JM07)

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Cell line name TIN2 F/F
Accession CVCL_JM07
Resource Identification Initiative To cite this cell line use: TIN2 F/F (RRID:CVCL_JM07)
Comments Characteristics: Embryonic fibroblasts that have loxP sites on both sides of the 1st coding exon of mouse Terf1 gene. Terf1 knockout can be effected by transduction of Cre recombinase into the cell line (ATCC=CRL-3318).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Transformed cell line
Publications

PubMed=22099311; DOI=10.1016/j.molcel.2011.08.043; PMCID=PMC3222871
Kaori K. Takai, Tatsuya Kibe, Jill R. Donigian, David Frescas, Titia de Lange;
Telomere protection by TPP1/POT1 requires tethering to TIN2.
Mol. Cell 44:647-659(2011)

Cross-references
Cell line collections (Providers) ATCC; CRL-3318
Encyclopedic resources Wikidata; Q54972491
Entry history
Entry creation15-May-2017
Last entry update14-Aug-2025
Version number9