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Cellosaurus HeLa-X4 (CVCL_JL48)

[Text version]
Cell line name HeLa-X4
Synonyms HeLa-X4-6
Accession CVCL_JL48
Resource Identification Initiative To cite this cell line use: HeLa-X4 (RRID:CVCL_JL48)
Comments Population: African American.
Characteristics: Engineered to express the gp160 envelope protein (Env) from a CXCR4-tropic HIV-1 isolate.
Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
Transfected with: HIV-1 isolate NL4-3 env.
Transfected with: UniProtKB; P04610; HIV-1 isolate BRU/LAI tat.
Transfected with: UniProtKB; P42212; GFP.
Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with p.Met1_Arg360del).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_IY74 (HeLa Tet-On)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=16314403; DOI=10.1177/1087057105282959
Ji C.-H., Zhang J., Cammack N., Sankuratri S.
Development of a novel dual CCR5-dependent and CXCR4-dependent cell-cell fusion assay system with inducible gp160 expression.
J. Biomol. Screen. 11:65-74(2006)

Cross-references
Encyclopedic resources Wikidata; Q54882735
Entry history
Entry creation15-May-2017
Last entry update05-Oct-2023
Version number10