| Cell line name |
S462.TY |
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| Synonyms |
S462-TY; S462TY |
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| Accession |
CVCL_JK02 |
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| Resource Identification Initiative |
To cite this cell line use: S462.TY (RRID:CVCL_JK02) |
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| Comments |
Characteristics: Was created by passage of S462 as xenografts.
Derived from site: In situ; Thigh; UBERON=UBERON_0000376. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous; Note=By translocation (from parent cell line).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Heterozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7765; NF1; Simple; p.Tyr2285Ter (c.6855C>A) (p.Tyr2264Ter, c.6792C>A); ClinVar=VCV000185082; Zygosity=Heterozygous; Note=Germline (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Pro (c.329G>C); ClinVar=VCV000233627; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1Y70 (S462) |
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| Sex of cell |
Female |
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| Age at sampling |
19Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=18281493; DOI=10.1158/0008-5472.CAN-07-2734; PMCID=PMC2855837
Mahller Y.Y., Vaikunth S.S., Ripberger M.C., Baird W.H., Saeki Y., Cancelas J.A., Crombleholme T.M., Cripe T.P.
Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.
Cancer Res. 68:1170-1179(2008) PubMed=28469964; PMCID=PMC5411799
Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R., Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C., Field J.
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_JK02
|
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| Encyclopedic resources |
Wikidata; Q54951929
|
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| Entry history |
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| Entry creation | 15-May-2017 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 13 |
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