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Cellosaurus S462 (CVCL_1Y70)

[Text version]
Cell line name S462
Synonyms Patient 6 cell line
Accession CVCL_1Y70
Resource Identification Initiative To cite this cell line use: S462 (RRID:CVCL_1Y70)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Tumorigenic (PubMed=37798904).
Doubling time: ~16 hours (PubMed=21084276); 1.61 days (PubMed=37798904).
Karyotypic information: Average ploidy of 3.85 (PubMed=36818284).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Thigh; UBERON=UBERON_0000376.
Sequence variations
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_JK02 (S462.TY)
Sex of cell Female
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC414; PubMed=28556483; PubMed=36818284

Markers:
AmelogeninX
CSF1PO12 (PubMed=36818284)
12,13 (Millipore=SCC414; PubMed=28556483)
D2S133823
D3S135814,17
D5S81812 (PubMed=36818284)
12,13 (Millipore=SCC414; PubMed=28556483)
D7S8208,10
D8S117910,12
D13S31712
D16S53911,13 (PubMed=36818284)
13 (Millipore=SCC414; PubMed=28556483)
D18S5116
D19S43314
D21S1129 (PubMed=36818284)
29,31 (Millipore=SCC414; PubMed=28556483)
FGA20
Penta D9,11
Penta E11
TH017,8 (PubMed=36818284)
8 (Millipore=SCC414; PubMed=28556483)
TPOX8
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=15207265; DOI=10.1016/j.nbd.2004.01.006
Silke Frahm, Victor-Felix Mautner, Hilde Brems, Eric Legius, Maria Debiec-Rychter, Reinhard E. Friedrich, Wolfram Trudo Knoefel, Matthias Peiper, Lan Kluwe;
Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients.
Neurobiol. Dis. 16:85-91(2004)

PubMed=15735744; DOI=10.1038/sj.onc.1208425
George Alexander Mashour, Stephanie Nicole Drissel, Silke Frahm, Faris Farassati, Robert Lawrence Martuza, Victor-Felix Mautner, Andrea Kindler-Rohrborn, Andreas Kurtz;
Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids.
Oncogene 24:2367-2374(2005)

PubMed=18650488; DOI=10.1215/15228517-2008-053; PMCID=PMC2719009
Nikola Holtkamp, Elke Malzer, Jan Zietsch, Ali Fuat Okuducu, Jana Mucha, Christian Mawrin, Victor-Felix Mautner, Hans-Ulrich Schildhaus, Andreas von Deimling;
EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy.
Neuro-oncol. 10:946-957(2008)

PubMed=21084276; DOI=10.1158/0008-5472.CAN-10-2799; PMCID=PMC3064267
Gonzalo Lopez, Keila Enitt Torres, Jeffrey Jue-Hui Liu, Belinda Hernandez, Eric D. Young, Roman Belousov, Svetlana V. Bolshakov, Alexander J.F. Lazar, John M. Slopis, Ian E. McCutcheon, David J. McConkey, Dina Chelouche Lev;
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.
Cancer Res. 71:185-196(2011)

PubMed=21695156; DOI=10.1371/journal.pone.0021099; PMCID=PMC3113907
Melanie Spyra, Lan Kluwe, Christian Hagel, Rosa Nguyen, Jens Panse, Andreas Kurtz, Victor-Felix Mautner, Samuel David Rabkin, Maria Demestre;
Cancer stem cell-like cells derived from malignant peripheral nerve sheath tumors.
PLoS ONE 6:e21099.1-e21099.9(2011)

PubMed=23437333; DOI=10.1371/journal.pone.0057152; PMCID=PMC3578816
David E. Reuss, Jana Mucha, Christian Hagenlocher, Volker Ehemann, Lan Kluwe, Victor-Felix Mautner, Andreas von Deimling;
Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.
PLoS ONE 8:e57152.1-e57152.10(2013)

PubMed=28556483; DOI=10.1002/1878-0261.12086; PMCID=PMC5579334
Matthias Kolberg, Jarle Bruun, Astrid Murumagi, John Patrick Mpindi, Christian H. Bergsland, Maren Holand, Ina A. Eilertsen, Stine A. Danielsen, Olli-Pekka Kallioniemi, Ragnhild Adelheid Lothe;
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors.
Mol. Oncol. 11:1156-1171(2017)

PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054
Alexander Pemov, Hua Li, William Presley, Margaret R. Wallace, David T. Miller;
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:i50-i61(2020)

PubMed=34059954; DOI=10.1007/s00439-021-02296-x
Miriam Magallon-Lorenz, Juana Fernandez-Rodriguez, Ernest Terribas, Edgar Creus-Bachiller, Cleofe Romagosa, Anna Estival, Diana Perez Sidelnikova, Hector Salvador, Alberto Villanueva, Ignacio Blanco, Meritxell Carrio ...Show all 14 authors... , Conxi Lazaro, Eduard Serra, Bernat Gel; Show fewer authors
Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.
Hum. Genet. 140:1241-1252(2021)

PubMed=36818284; DOI=10.1016/j.isci.2023.106096; PMCID=PMC9929861
Miriam Magallon-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernandez, Gerard Requena, Inma Rosas, Helena Mazuelas, Itziar Uriarte-Arrazola, Alex Negro, Tereza Lausova ...Show all 28 authors... , Elisabeth Castellanos, Ignacio Blanco, George Henry DeVries, Hiroyuki Kawashima, Eric Legius, Hilde Brems, Victor-Felix Mautner, Lan Kluwe, Nancy Ratner, Margaret R. Wallace, Juana Fernandez-Rodriguez, Conxi Lazaro, Jonathan A. Fletcher, David E. Reuss, Meritxell Carrio, Bernat Gel, Eduard Serra; Show fewer authors
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
iScience 26:106096.1-106096.22(2023)

PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238
Edgar Creus-Bachiller, Juana Fernandez-Rodriguez, Miriam Magallon-Lorenz, Sara Ortega-Bertran, Susana Navas-Rutete, Cleofe Romagosa, Tulio M. Silva, Maria Pane Foix, Anna Estival, Diana Perez Sidelnikova, Mireia Morell Ginesta ...Show all 19 authors... , Helena Mazuelas, Meritxell Carrio, Tereza Lausova, David E. Reuss, Bernat Gel, Alberto Villanueva, Eduard Serra, Conxi Lazaro; Show fewer authors
Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: new patient-derived orthotopic xenografts, cell lines and tumor entities.
Mol. Oncol. 18:895-917(2024)

Cross-references
Cell line collections (Providers) Millipore; SCC414
Cell line databases/resources cancercelllines; CVCL_1Y70
DepMap; ACH-002693
Encyclopedic resources Wikidata; Q54951928
Experimental variables resources EFO; EFO_0006292
Polymorphism and mutation databases Cosmic; 1132062
Cosmic; 1801809
Entry history
Entry creation22-Sep-2015
Last entry update10-Apr-2025
Version number16