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Cellosaurus Ben-Men-1-LucB (CVCL_JK01)

[Text version]
Cell line name Ben-Men-1-LucB
Accession CVCL_JK01
Resource Identification Initiative To cite this cell line use: Ben-Men-1-LucB (RRID:CVCL_JK01)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Brain, falx cerebri; UBERON=UBERON_0006059.
Sequence variations
  • Mutation; HGNC; HGNC:7773; NF2; Simple; p.Leu214fs*6 (c.640delC); Zygosity=Hemizygous (PubMed=23151902).
Disease Meningothelial meningioma (NCIt: C4329)
Meningioma (ORDO: Orphanet_2495)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1959 (Ben-Men-1)
Sex of cell Female
Age at sampling 68Y
Category Telomerase immortalized cell line
Publications

PubMed=23151902; DOI=10.1158/0008-5472.CAN-12-1888; PMCID=PMC3549000
Sarah S. Burns, Elena M. Akhmametyeva, Janet L. Oblinger, Matthew L. Bush, Jie Huang, Volker Senner, Ching-Shih Chen, Abraham Jacob, Duane Bradley Welling, Long-Sheng Chang;
Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth.
Cancer Res. 73:792-803(2013)

PubMed=25596744; DOI=10.18632/oncotarget.2810; PMCID=PMC4385830
Hoi-Yee Chow, Biao Dong, Sergio G. Duron, David A. Campbell, Christy C. Ong, Klaus P. Hoeflich, Long-Sheng Chang, Duane Bradley Welling, Zeng-Jie Yang, Jonathan Chernoff;
Group I Paks as therapeutic targets in NF2-deficient meningioma.
Oncotarget 6:1981-1994(2015)

Cross-references
Encyclopedic resources Wikidata; Q54796000
Entry history
Entry creation15-May-2017
Last entry update14-Aug-2025
Version number13