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Cellosaurus Ben-Men-1 (CVCL_1959)

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Cell line name Ben-Men-1
Synonyms BEN-MEN-1; BenMen 1; Benign-Meningioma-1
Accession CVCL_1959
Resource Identification Initiative To cite this cell line use: Ben-Men-1 (RRID:CVCL_1959)
Comments Doubling time: 25.6 hours (PubMed=15965488); ~40-50 hours (DSMZ=ACC-599).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Brain, falx cerebri; UBERON=UBERON_0006059.
Sequence variations
Disease Meningothelial meningioma (NCIt: C4329)
Meningioma (ORDO: Orphanet_2495)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_JK01 (Ben-Men-1-LucB)
Sex of cell Female
Age at sampling 68Y
Category Telomerase immortalized cell line
STR profile Source(s): DSMZ=ACC-599

Markers:
AmelogeninX
CSF1PO10,11
D2S133820,25
D3S135816
D5S81812,13
D7S8209
D8S117911,12
D13S31711,12
D16S53913
D18S5114,17
D19S43314,15
D21S1129,32.2
FGA21,22
Penta D10,11
Penta E10,11
TH019
TPOX8,11
vWA14,18

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Publications

PubMed=15965488; DOI=10.1038/labinvest.3700307
Sylvia Puttmann, Volker Senner, Stephan Braune, Beate Hillmann, Rita Exeler, Christian H. Rickert, Werner Paulus;
Establishment of a benign meningioma cell line by hTERT-mediated immortalization.
Lab. Invest. 85:1163-1171(2005)

PubMed=23151902; DOI=10.1158/0008-5472.CAN-12-1888; PMCID=PMC3549000
Sarah S. Burns, Elena M. Akhmametyeva, Janet L. Oblinger, Matthew L. Bush, Jie Huang, Volker Senner, Ching-Shih Chen, Abraham Jacob, Duane Bradley Welling, Long-Sheng Chang;
Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth.
Cancer Res. 73:792-803(2013)

PubMed=28552950; DOI=10.1371/journal.pone.0178322; PMCID=PMC5446134
Yu Mei, Wen-Ya Linda Bi, Noah F. Greenwald, Nathalie Yvonne Rachel Agar, Rameen Beroukhim, Gavin P. Dunn, Ian F. Dunn;
Genomic profile of human meningioma cell lines.
PLoS ONE 12:e0178322.1-e0178322.12(2017)

Cross-references
Cell line collections (Providers) DSMZ; ACC-599
Cell line databases/resources DSMZCellDive; ACC-599
Anatomy/cell type resources BTO; BTO_0004399
Biological sample resources BioSample; SAMN03473495
Encyclopedic resources Wikidata; Q54795998
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number27