Cellosaurus cell line KT-1/A3R (CVCL

Cross-references
Cell line name	KT-1/A3R
Synonyms	KT-1/A3Ralpha 1000; A3R
Accession	CVCL_JH31
Resource Identification Initiative	To cite this cell line use: KT-1/A3R (RRID:CVCL_JH31)
Comments	Population: Japanese. Characteristics: Interferon-alpha resistant. Can proliferate and is resistant to apoptosis at high concentration of IFN-alpha. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
Disease	Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174) Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_JH29 (KT-1/A3)
Sex of cell	Male
Age at sampling	32Y
Category	Cancer cell line
Publications	PubMed=11506301; DOI=10.2169/internalmedicine.40.607 Hayato Yamauchi, Ikuya Sakai, Hirosi Narumi, Kazuto Takeuchi, Shinji Soga, Shigeru Fujita; Development of interferon-alpha resistant subline from human chronic myelogenous leukemia cell line KT-1. Intern. Med. 40:607-612(2001) PubMed=12351404; DOI=10.1182/blood-2002-01-0073 Ikuya Sakai, Kazuto Takeuchi, Hayato Yamauchi, Hirosi Narumi, Shigeru Fujita; Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells. Blood 100:2926-2931(2002)
Encyclopedic resources	Wikidata; Q54900521
Entry history
Entry creation	15-May-2017
Last entry update	14-Aug-2025
Version number	9