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Cellosaurus C5.2 (CVCL_J984)

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Cell line name C5.2
Synonyms HB4a-C5.2
Accession CVCL_J984
Resource Identification Initiative To cite this cell line use: C5.2 (RRID:CVCL_J984)
Comments Characteristics: High expression of ERBB2 (PubMed=9935193).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3430; ERBB2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58+U19).
Omics: Transcriptomics; Massively parallel signature sequencing (MPSS).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_J982 (HB4a)
Sex of cell Female
Age at sampling 18Y
Category Conditionally immortalized cell line
Publications

PubMed=9935193; DOI=10.1002/(SICI)1097-0215(19990129)80:3<477::AID-IJC23>3.0.CO;2-W
Robert A. Harris, Thomas J. Eichholtz, Ian D. Hiles, Martin J. Page, Michael J. O'Hare;
New model of ErbB-2 over-expression in human mammary luminal epithelial cells.
Int. J. Cancer 80:477-484(1999)

CLPUB00734
Ana Paula Medeiros Silva, Dirce Maria Carraro, Lilian Campos Pires, Cornelis Victor Jongeneel, Sandro Jose De Souza, Anamaria Aranha Camargo;
Characterization of novel c-erbB2 regulated genes using massively parallel signature sequencing (MPSS).
Cancer Res. 66 Suppl. 8:19-20(2006)

PubMed=16685446; DOI=10.3892/ijo.28.6.1441
Mariana Lopes dos Santos, Carolina Goncalves Palanch, Sibeli Salaorni, Wilson Araujo da Silva Jr., Maria Aparecida Nagai;
Transcriptome characterization of human mammary cell lines expressing different levels of ERBB2 by serial analysis of gene expression.
Int. J. Oncol. 28:1441-1461(2006)

Cross-references
Encyclopedic resources Wikidata; Q54808190
Entry history
Entry creation11-Feb-2013
Last entry update14-Aug-2025
Version number16