Cellosaurus cell line A-HER2 (CVCL

Cellosaurus A-HER2 (CVCL_J973)

Cross-references
Cell line name	A-HER2
Synonyms	4D5; NB9644P28
Accession	CVCL_J973
Resource Identification Initiative	To cite this cell line use: A-HER2 (RRID:CVCL_J973)
Comments	Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10463. Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized trastuzumab (herceptin) therapeutic antibody. Monoclonal antibody isotype: IgG1, kappa. Monoclonal antibody target: UniProtKB; P04626; Human ERBB2/CD340.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy	Parent: CVCL_4032 (P3X63Ag8.653)
Category	Hybridoma
Publications	PubMed=2566907; DOI=10.1128/mcb.9.3.1165-1172.1989; PMCID=PMC362707 Robert M. Hudziak, Gail D. Lewis Phillips, Marcy Winget, Brian M. Fendly, H. Michael Shepard, Axel Ullrich; p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Mol. Cell. Biol. 9:1165-1172(1989) PubMed=1689212 Brian M. Fendly, Marcy Winget, Robert M. Hudziak, Michael T. Lipari, Mary Anna Napier, Axel Ullrich; Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product. Cancer Res. 50:1550-1558(1990) Patent=US5677171 Robert M. Hudziak, H. Michael Shepard, Axel Ullrich, Brian M. Fendly; Monoclonal antibodies directed to the HER2 receptor. Patent number US5677171, 14-Oct-1997 Patent=US10280228 Sharon A. Baughman, Steven Shak; Treatment with anti-ErbB2 antibodies. Patent number US10280228, 07-May-2019
Cell line databases/resources	CLO; CLO_0001687
Encyclopedic resources	Wikidata; Q54606072
Entry history
Entry creation	11-Feb-2013
Last entry update	21-Mar-2023
Version number	9