ID   A-HER2
AC   CVCL_J973
SY   4D5; NB9644P28
DR   CLO; CLO_0001687
DR   Wikidata; Q54606072
RX   Patent=US5677171;
RX   Patent=US10280228;
RX   PubMed=1689212;
RX   PubMed=2566907;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10463.
CC   Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized trastuzumab (herceptin) therapeutic antibody.
CC   Monoclonal antibody isotype: IgG1, kappa.
CC   Monoclonal antibody target: UniProtKB; P04626; Human ERBB2/CD340.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_4032 ! P3X63Ag8.653
CA   Hybridoma
DT   Created: 11-02-13; Last updated: 21-03-23; Version: 9
//
RX   Patent=US5677171;
RA   Hudziak R.M., Shepard H.M., Ullrich A., Fendly B.M.;
RT   "Monoclonal antibodies directed to the HER2 receptor.";
RL   Patent number US5677171, 14-Oct-1997.
//
RX   Patent=US10280228;
RA   Baughman S.A., Shak S.;
RT   "Treatment with anti-ErbB2 antibodies.";
RL   Patent number US10280228, 07-May-2019.
//
RX   PubMed=1689212;
RA   Fendly B.M., Winget M., Hudziak R.M., Lipari M.T., Napier M.A.,
RA   Ullrich A.;
RT   "Characterization of murine monoclonal antibodies reactive to either
RT   the human epidermal growth factor receptor or HER2/neu gene product.";
RL   Cancer Res. 50:1550-1558(1990).
//
RX   PubMed=2566907; DOI=10.1128/mcb.9.3.1165-1172.1989;
RA   Hudziak R.M., Lewis Phillips G.D., Winget M., Fendly B.M.,
RA   Shepard H.M., Ullrich A.;
RT   "p185HER2 monoclonal antibody has antiproliferative effects in vitro
RT   and sensitizes human breast tumor cells to tumor necrosis factor.";
RL   Mol. Cell. Biol. 9:1165-1172(1989).
//