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Cellosaurus MDA 435TR (CVCL_J435)

[Text version]
Cell line name MDA 435TR
Synonyms MDA 435(TR)
Accession CVCL_J435
Resource Identification Initiative To cite this cell line use: MDA 435TR (RRID:CVCL_J435)
Comments Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0417 (MDA-MB-435)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_J435
Encyclopedic resources Wikidata; Q54904548
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number22