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Cellosaurus RPMI-8226/LR-5 (CVCL_J434)

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Cell line name RPMI-8226/LR-5
Synonyms RPMI-8226 LR5; RPMI8226-LR5; RPMI 8226/LR5; 8226/LR-5; 8226/LR5
Accession CVCL_J434
Resource Identification Initiative To cite this cell line use: RPMI-8226/LR-5 (RRID:CVCL_J434)
Comments Population: African American.
Characteristics: Produces IgG lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_28876; Melphalan (L-phenylalanine mustard; LPAM; Alkeran).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; HGNC:5865; IGLJ3 + HGNC; HGNC:5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=1988143
William T. Bellamy, William S. Dalton, Mary C. Gleason-Guzman, Thomas M. Grogan, Jeffrey M. Trent;
Development and characterization of a melphalan-resistant human multiple myeloma cell line.
Cancer Res. 51:995-1002(1991)

Cross-references
Cell line databases/resources cancercelllines; CVCL_J434
Encyclopedic resources Wikidata; Q54951248
Gene expression databases GEO; GSM562820
Proteomic databases PRIDE; PXD001276
Entry history
Entry creation11-Feb-2013
Last entry update14-Aug-2025
Version number23