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Cellosaurus RPMI-8226/Dox40 (CVCL_J431)

[Text version]
Cell line name RPMI-8226/Dox40
Synonyms RPMI 8226/DOX40; RPMI-8226DOX40; 8226/DOX40; 8226/Dox40; 8226/Dox(40); 8226 Dox40; Dox40
Accession CVCL_J431
Resource Identification Initiative To cite this cell line use: RPMI-8226/Dox40 (RRID:CVCL_J431)
Comments Population: African American.
Characteristics: Produces IgG lambda.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; 5865; IGLJ3 + HGNC; 5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
CVCL_J433 (RPMI-8226/MDR10V)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line

Tong A.W., Lee J., Wang R.-M., Dalton W.S., Tsuruo T., Fay J.W., Stone M.J.
Elimination of chemoresistant multiple myeloma clonogenic colony-forming cells by combined treatment with a plasma cell-reactive monoclonal antibody and a P-glycoprotein-reactive monoclonal antibody.
Cancer Res. 49:4829-4834(1989)

PubMed=10095106; DOI=10.1016/S0378-1119(99)00042-6
Duan Z.-F., Feller A.J., Toh H.C., Makastorsis T., Seiden M.V.
TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line.
Gene 229:75-81(1999)

Scheffer G.L., Maliepaard M., Pijnenborg A.C.L.M., van Gastelen M.A., de Jong M.C., Schroeijers A.B., van der Kolk D.M., Allen J.D., Ross D.D., van der Valk P., Dalton W.S., Schellens J.H.M., Scheper R.J.
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines.
Cancer Res. 60:2589-2593(2000)

Maliepaard M., Scheffer G.L., Faneyte I.F., van Gastelen M.A., Pijnenborg A.C.L.M., Schinkel A.H., van de Vijver M.J., Scheper R.J., Schellens J.H.M.
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Cancer Res. 61:3458-3464(2001)

Cell line databases/resources cancercelllines; CVCL_J431
Encyclopedic resources Wikidata; Q54951246
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number17