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Cellosaurus CEM-ON (CVCL_J395)

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Cell line name CEM-ON
Synonyms AGR-ON
Accession CVCL_J395
Resource Identification Initiative To cite this cell line use: CEM-ON (RRID:CVCL_J395)
Comments Group: Hybridoma fusion partner cell line.
Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8199.
Population: Caucasian.
Characteristics: Constitutively secretes CSF1 (PubMed=3259875).
Characteristics: Can be used as a fusion partner for constructing T-cell hybridomas (ATCC=CRL-8199).
Selected for resistance to: ChEBI; CHEBI_63486; 8-azaguanine.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_J396 (CEM-AGR)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
STR profile Source(s): ATCC=CRL-8199

Markers:
AmelogeninX
CSF1PO10,11
D5S81812
D7S82010,13
D13S31711,13
D16S53910,13
TH016,7
TPOX8
vWA17,19

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Publications

Patent=US4675291
Yuichi Yamamura, Tadamitsu Kishimoto, Satoru Nakai, Yoshikatsu Hirai;
Human cultured cell line.
Patent number US4675291, 23-Jun-1987

PubMed=3259875; DOI=10.1016/S0006-291X(88)80441-8
Masayuki Takahashi, Yeong-Man Hong, Setsuko Yasuda, Masaaki Takano, Kazuyoshi Kawai, Satoru Nakai, Yoshikatsu Hirai;
Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis.
Biochem. Biophys. Res. Commun. 152:1401-1409(1988)

Cross-references
Cell line collections (Providers) ATCC; CRL-8199 - Discontinued
Cell line databases/resources CLO; CLO_0009832
cancercelllines; CVCL_J395
Cell_Model_Passport; SIDM01249
LINCS_LDP; LCL-1033
Biological sample resources BioSample; SAMN03471198
Encyclopedic resources Wikidata; Q54809252
Entry history
Entry creation11-Feb-2013
Last entry update19-Dec-2024
Version number29