ID   CEM-ON
AC   CVCL_J395
SY   AGR-ON
DR   CLO; CLO_0009832
DR   ATCC; CRL-8199
DR   BioSample; SAMN03471198
DR   cancercelllines; CVCL_J395
DR   Cell_Model_Passport; SIDM01249
DR   LINCS_LDP; LCL-1033
DR   Wikidata; Q54809252
RX   Patent=US4675291;
RX   PubMed=3259875;
CC   Group: Hybridoma fusion partner cell line.
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8199.
CC   Population: Caucasian.
CC   Characteristics: Constitutively secretes CSF1 (PubMed=3259875).
CC   Characteristics: Can be used as a fusion partner for constructing T-cell hybridomas (ATCC=CRL-8199).
CC   Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Discontinued: ATCC; CRL-8199; true.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): ATCC=CRL-8199
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,13
ST   D16S539: 10,13
ST   D5S818: 12
ST   D7S820: 10,13
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 17,19
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_J396 ! CEM-AGR
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 02-05-24; Version: 28
//
RX   Patent=US4675291;
RA   Yamamura Y., Kishimoto T., Nakai S., Hirai Y.;
RT   "Human cultured cell line.";
RL   Patent number US4675291, 23-Jun-1987.
//
RX   PubMed=3259875; DOI=10.1016/S0006-291X(88)80441-8;
RA   Takahashi M., Hong Y.-M., Yasuda S., Takano M., Kawai K., Nakai S.,
RA   Hirai Y.;
RT   "Macrophage colony-stimulating factor is produced by human T
RT   lymphoblastoid cell line, CEM-ON: identification by amino-terminal
RT   amino acid sequence analysis.";
RL   Biochem. Biophys. Res. Commun. 152:1401-1409(1988).
//