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Cellosaurus FM3A tsFT101 (CVCL_J378)

[Text version]
Cell line name FM3A tsFT101
Synonyms FM3A FT-101; tsFT101
Accession CVCL_J378
Resource Identification Initiative To cite this cell line use: FM3A tsFT101 (RRID:CVCL_J378)
Comments Characteristics: Temperature sensitive phenotype. Cytokinesis is blocked at 39 Celsius.
Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Sequence variations
  • Mutation; MGI; MGI:1927222; Diaph3; Simple; p.Ile733Asn (c.2198T>A); Zygosity=Homozygous (PubMed=33187357).
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H/He.
Hierarchy Parent: CVCL_3869 (FM3A)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2581712; DOI=10.1247/csf.10.79
Hidetaro Yasumitsu, Fumio Hanaoka, Hideyo Yasuda, Yasufumi Murakami, Takemi Enomoto, Masa-atsu Yamada;
Isolation and initial characterization of a temperature-sensitive mutant of mouse FM3A cells defective in cytokinesis.
Cell Struct. Funct. 10:79-88(1985)

PubMed=9211798; DOI=10.1007/s004240050406
Yu Cao, Katsuaki Motomura, Akira Ohtsuru, Takaaki Matsumoto, Shunichi Yamashita, Mitsuo Kosaka;
Profilin gene expression and regulation in a temperature-sensitive breast cancer cell line: tsFT101.
Pflugers Arch. 434:341-345(1997)

PubMed=33187357; DOI=10.3390/ijms21228493; PMCID=PMC7696919
Hiroki Kazama, Shu-ichiro Kashiwaba, Sayaka Ishii, Keiko Yoshida, Yuta Yatsuo, Takuma Naraoka, Masashi Fukuoka, Yasufumi Murakami;
Loss of DIAPH3, a formin family protein, leads to cytokinetic failure only under high temperature conditions in mouse FM3A cells.
Int. J. Mol. Sci. 21:8493.1-8493.17(2020)

Cross-references
Cell line collections (Providers) JCRB; JCRB0706
RCB; RCB0032
Cell line databases/resources CLO; CLO_0050961
Encyclopedic resources Wikidata; Q54835034
Entry history
Entry creation11-Feb-2013
Last entry update14-Aug-2025
Version number11