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Cellosaurus TF-1 BCR/ABL (CVCL_J294)

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Cell line name TF-1 BCR/ABL
Synonyms TF-1 BCR-ABL
Accession CVCL_J294
Resource Identification Initiative To cite this cell line use: TF-1 BCR/ABL (RRID:CVCL_J294)
Comments Population: Japanese.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:76; ABL1 (Note=BCR-ABL1 fusion).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1014; BCR (Note=BCR-ABL1 fusion).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:15868; ABHD12 + HGNC; HGNC:1537; CBFA2T3; Name(s)=CBFA2T3-ABHD12 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Pro (c.182A>C); ClinVar=VCV000280409; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile251Thrfs*94 (c.752delT); ClinVar=VCV001759367; Zygosity=Unspecified (from parent cell line).
Disease Erythroleukemia (NCIt: C7152)
Acute erythroid leukemia (ORDO: Orphanet_318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0559 (TF-1)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=18829496; DOI=10.1158/1078-0432.CCR-08-0461
Seiichi Okabe, Tetsuzo Tauchi, Kazuma Ohyashiki;
Characteristics of dasatinib- and imatinib-resistant chronic myelogenous leukemia cells.
Clin. Cancer Res. 14:6181-6186(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_J294
Anatomy/cell type resources BTO; BTO_0004761
Encyclopedic resources Wikidata; Q54972198
Entry history
Entry creation11-Feb-2013
Last entry update19-Dec-2024
Version number17