Cellosaurus cell line 786-O-Luc [JCRB] (CVCL

Cellosaurus 786-O-Luc [JCRB] (CVCL_J240)

Cross-references
Cell line name	786-O-Luc [JCRB]
Synonyms	786-0-Luc
Accession	CVCL_J240
Resource Identification Initiative	To cite this cell line use: 786-O-Luc [JCRB] (RRID:CVCL_J240)
Comments	Population: Caucasian. Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations	Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-2A>G; ClinVar=VCV003148158; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease	Renal cell carcinoma (NCIt: C9385) Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1051 (786-O)
Sex of cell	Male
Age at sampling	58Y
Category	Cancer cell line
Cell line collections (Providers)	JCRB; JCRB1397 JCRB; NIHS0651 - Discontinued
Cell line databases/resources	cancercelllines; CVCL_J240
Encyclopedic resources	Wikidata; Q54604951
Entry history
Entry creation	11-Feb-2013
Last entry update	14-Aug-2025
Version number	22