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Cellosaurus UROtsa Cd#1 (CVCL_IX03)

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Cell line name UROtsa Cd#1
Synonyms UTCd#1; UROtsa_Cd_1
Accession CVCL_IX03
Resource Identification Initiative To cite this cell line use: UROtsa Cd#1 (RRID:CVCL_IX03)
Comments Characteristics: Tumorigenic derivative of UROtsa. Subcutaneous injection of this cell line in nude mice produces tumors.
Doubling time: 27.8 +- 0.6 hours (PubMed=19921857).
Transformant: ChEBI; CHEBI_48775; Cadmium(2+).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Urinary bladder, urothelium; UBERON=UBERON_0004645.
Cell type: Urothelial cell; CL=CL_0000731.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0571 (UROtsa)
Children:
CVCL_LM65 (UROtsa Cd#1-SPARC)
Sex of cell Female
Age at sampling 12Y
Category Transformed cell line
Publications

PubMed=19921857; DOI=10.1021/tx900346q; PMCID=PMC2822111
Seema Somji, Xu-Dong Zhou, Aaron Mehus, Mary Ann Sens, Scott H. Garrett, Krista L. Lutz, Jane R. Dunlevy, Yun Zheng, Donald A. Sens;
Variation of keratin 7 expression and other phenotypic characteristics of independent isolates of cadmium transformed human urothelial cells (UROtsa).
Chem. Res. Toxicol. 23:348-356(2010)

PubMed=26783756; DOI=10.1371/journal.pone.0147362; PMCID=PMC4718619
Andrea Slusser-Nore, Jennifer L. Larson-Casey, Ruo-Wen Zhang, Xu-Dong Zhou, Seema Somji, Scott H. Garrett, Donald A. Sens, Jane R. Dunlevy;
SPARC expression is selectively suppressed in tumor initiating urospheres isolated from As+3- and Cd+2-transformed human urothelial cells (UROtsa) stably transfected with SPARC.
PLoS ONE 11:e0147362.1-e0147362.22(2016)

PubMed=30550540; DOI=10.1371/journal.pone.0207877; PMCID=PMC6294394
Zachary E. Hoggarth, Danyelle B. Osowski, Brooke Alexandra Freeberg, Scott H. Garrett, Donald A. Sens, Mary Ann Sens, Xu-Dong Zhou, Ke K. Zhang, Seema Somji;
The urothelial cell line UROtsa transformed by arsenite and cadmium display basal characteristics associated with muscle invasive urothelial cancers.
PLoS ONE 13:e0207877.1-e0207877.26(2018)

Cross-references
Encyclopedic resources Wikidata; Q54991826
Entry history
Entry creation15-May-2017
Last entry update19-Dec-2024
Version number9