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Cellosaurus A375/R (CVCL_IW10)

[Text version]
Cell line name A375/R
Accession CVCL_IW10
Resource Identification Initiative To cite this cell line use: A375/R (RRID:CVCL_IW10)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90295; PLX-4720 (PLX4720).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line

PubMed=26365896; DOI=10.1016/j.molonc.2015.08.003
Baenke F., Chaneton B., Smith M., van den Broek N., Hogan K., Tang H.-R., Viros A., Martin M., Galbraith L., Girotti M.R., Dhomen N., Gottlieb E., Marais R.
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells.
Mol. Oncol. 10:73-84(2016)

Cell line databases/resources cancercelllines; CVCL_IW10
Chemistry resources ChEMBL-Cells; CHEMBL4296205
ChEMBL-Targets; CHEMBL4296383
PubChem_Cell_line; CVCL_IW10
Encyclopedic resources Wikidata; Q54606867
Entry history
Entry creation03-Mar-2017
Last entry update05-Oct-2023
Version number15