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Cellosaurus CHP-100L (CVCL_IV94)

[Text version]
Cell line name CHP-100L
Synonyms CHP-100-L; CHP100L; CHP-100 Large
Accession CVCL_IV94
Resource Identification Initiative To cite this cell line use: CHP-100L (RRID:CVCL_IV94)
Comments Problematic cell line: Misclassified. Parent cell line (CHP-100) was originally thought to originate from a neuroblastoma but was later shown to be from an Ewing sarcoma.
Part of: MD Anderson Cell Lines Project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00610.
Doubling time: 21 hours (PubMed=6825097).
Omics: Protein expression by reverse-phase protein arrays.
Derived from site: In situ; Bone, spine, epidural space; UBERON=UBERON_0003691.
Sequence variations
  • Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 2 fusion (Ex7/Ex5) (PubMed=25010205).
  • Mutation; HGNC; 11998; TP53; Simple; p.His233fs (c.696_697ins4); Zygosity=Unspecified (PubMed=25010205).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7166 (CHP-100)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): PubMed=25010205; PubMed=33460449


Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/

Bernal S.D., Thompson R., Gilbert F., Baylin S.B.
In vitro and in vivo growth characteristics of two different cell populations in an established line of human neuroblastoma.
Cancer Res. 43:1256-1260(1983)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475
Brohl A.S., Solomon D.A., Chang W., Wang J.-J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H.-L., Wen X.-Y., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M.M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=33460449; DOI=10.1002/ijc.33474
Dirks W.G., Capes-Davis A., Eberth S., Fahnrich S., Wilting J., Nagel S., Steenpass L., Becker J.
Cross-contamination meets misclassification: awakening of CHP-100 from sleeping beauty sleep -- a reviewed model for Ewing's sarcoma.
Int. J. Cancer 148:2608-2613(2021)

Encyclopedic resources Wikidata; Q54813261
Polymorphism and mutation databases Cosmic; 2228221
Entry history
Entry creation03-Mar-2017
Last entry update02-May-2024
Version number11