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Cellosaurus CHP-100L (CVCL_IV94)

[Text version]
Cell line name CHP-100L
Synonyms CHP-100-L; CHP100L; CHP-100 Large
Accession CVCL_IV94
Resource Identification Initiative To cite this cell line use: CHP-100L (RRID:CVCL_IV94)
Comments Problematic cell line: Misclassified. Parent cell line (CHP-100) was originally thought to originate from a neuroblastoma but was later shown to be from an Ewing sarcoma.
Part of: MD Anderson Cell Lines Project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00610.
Doubling time: 21 hours (PubMed=6825097).
Omics: Proteomics; Expression; Reverse-phase protein array.
Derived from site: In situ; Bone, spine, epidural space; UBERON=UBERON_0003691.
Sequence variations
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 2 fusion (Ex7/Ex5) (PubMed=25010205).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His233fs (c.696_697ins4); Zygosity=Unspecified (PubMed=25010205).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7166 (CHP-100)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): PubMed=25010205; PubMed=33460449

Markers:
AmelogeninX
CSF1PO12,13
D2S133818,21
D3S135816
D5S81811,12
D7S8209,10
D8S117912,15
D13S31711,13
D16S53910
D18S5112,17
D19S43313
D21S1129
TH016,9.3
TPOX8,9
vWA17,19

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=6825097
Samuel Dequina Bernal, RoxAnna Thompson, Fred Gilbert, Stephen Bruce Baylin;
In vitro and in vivo growth characteristics of two different cell populations in an established line of human neuroblastoma.
Cancer Res. 43:1256-1260(1983)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=33460449; DOI=10.1002/ijc.33474
Wilhelm Gerhard Dirks, Amanda Capes-Davis, Sonja Eberth, Silke Fahnrich, Jorg Wilting, Stefan Nagel, Laura Steenpass, Jennifer Becker;
Cross-contamination meets misclassification: awakening of CHP-100 from sleeping beauty sleep -- a reviewed model for Ewing's sarcoma.
Int. J. Cancer 148:2608-2613(2021)

Cross-references
Encyclopedic resources Wikidata; Q54813261
Polymorphism and mutation databases Cosmic; 2228221
Entry history
Entry creation03-Mar-2017
Last entry update10-Apr-2025
Version number13