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Cellosaurus USPC-ARK-2 (CVCL_IV73)

[Text version]
Cell line name USPC-ARK-2
Synonyms USPC ARK-2; USPC-ARK2; USC ARK-2; ARK-2; ARK2
Accession CVCL_IV73
Resource Identification Initiative To cite this cell line use: USPC-ARK-2 (RRID:CVCL_IV73)
Comments Population: African American.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Disease Endometrial serous adenocarcinoma (NCIt: C27838)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=19920829; DOI=10.1038/sj.bjc.6605448; PMCID=PMC2813756
Karim S. El-Sahwi, Stefania Bellone, Emiliano Cocco, Marilisa Cargnelutti, Francesca Casagrande, Marta Bellone, Maysa Abu-Khalaf, Natalia Buza, Fattaneh A. Tavassoli, Pei Hui, Dan-Arin Silasi ...Show all 16 authors... , Masoud Azodi, Peter E. Schwartz, Thomas J. Rutherford, Sergio Pecorelli, Alessandro D. Santin; Show fewer authors
In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma.
Br. J. Cancer 102:134-143(2010)

PubMed=21246534; DOI=10.1002/cncr.25891; PMCID=PMC3128671
Joyce Varughese, Emiliano Cocco, Stefania Bellone, Maria de Leon, Marta Bellone, Paola Todeschini, Peter E. Schwartz, Thomas J. Rutherford, Sergio Pecorelli, Alessandro D. Santin;
Uterine serous papillary carcinomas overexpress human trophoblast-cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized anti-Trop-2 monoclonal antibody.
Cancer 117:3163-3172(2011)

PubMed=23891627; DOI=10.1016/j.ajog.2013.07.020
Diana P. English, Stefania Bellone, Emiliano Cocco, Ileana Bortolomai, Sergio Pecorelli, Salvatore Lopez, Dan-Arin Silasi, Peter E. Schwartz, Thomas J. Rutherford, Alessandro D. Santin;
Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2).
Am. J. Obstet. Gynecol. 209:465.e1-465.e9(2013)

PubMed=25268372; DOI=10.1038/bjc.2014.519; PMCID=PMC4453741
Carlton L. Schwab, Stefania Bellone, Diana P. English, Dana Marie Roque, S. Lopez, Emiliano Cocco, Roberta Nicoletti, Ileana Bortolomai, Elena Bonazzoli, Elena Ratner, Dan-Arin Silasi ...Show all 15 authors... , Masoud Azodi, Peter E. Schwartz, Thomas J. Rutherford, Alessandro D. Santin; Show fewer authors
Afatinib demonstrates remarkable activity against HER2-amplified uterine serous endometrial cancer in vitro and in vivo.
Br. J. Cancer 111:1750-1756(2014)

PubMed=26325104; DOI=10.1038/bjc.2015.306; PMCID=PMC4651122
Jonathan D. Black, Salvatore Lopez, Emiliano Cocco, Stefania Bellone, Gary Altwerger, Carlton L. Schwab, Diana P. English, Elena Bonazzoli, Federica Predolini, Francesca Ferrari, Elena Ratner ...Show all 15 authors... , Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Alessandro D. Santin; Show fewer authors
PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas.
Br. J. Cancer 113:1020-1026(2015)

PubMed=26625219; DOI=10.1038/bjc.2015.388; PMCID=PMC4705897
Jonathan D. Black, Salvatore Lopez, Emiliano Cocco, Stefania Bellone, Gary Altwerger, Carlton L. Schwab, Diana P. English, Elena Bonazzoli, Federica Predolini, Francesca Ferrari, Elena Ratner ...Show all 15 authors... , Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Alessandro D. Santin; Show fewer authors
Erratum to: PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas.
Br. J. Cancer 113:1641-1641(2015)

PubMed=27894751; DOI=10.1016/j.ygyno.2016.11.023; PMCID=PMC5183545
Stefania Bellone, Eliana Bignotti, Silvia Lonardi, Francesca Ferrari, Floriana Centritto, Alice Masserdotti, Francesca Pettinella, Jonathan D. Black, Gulden Menderes, Gary Altwerger, Pei Hui ...Show all 29 authors... , Salvatore Lopez, Christopher de Haydu, Elena Bonazzoli, Federica Predolini, Luca Zammataro, Emiliano Cocco, Federico Ferrari, Antonella Ravaggi, Chiara Romani, Fabio Facchetti, Enrico Sartori, Franco Edoardo Odicino, Dan-Arin Silasi, Babak Litkouhi, Elena Ratner, Masoud Azodi, Peter E. Schwartz, Alessandro D. Santin; Show fewer authors
Polymerase epsilon (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro.
Gynecol. Oncol. 144:146-152(2017)

Cross-references
Encyclopedic resources Wikidata; Q54991963
Polymorphism and mutation databases Cosmic; 2640558
Entry history
Entry creation03-Mar-2017
Last entry update29-Jun-2023
Version number5