ID   USPC-ARK-2
AC   CVCL_IV73
SY   USPC ARK-2; USPC-ARK2; USC ARK-2; ARK-2; ARK2
DR   Cosmic; 2640558
DR   Wikidata; Q54991963
RX   PubMed=19920829;
RX   PubMed=21246534;
RX   PubMed=23891627;
RX   PubMed=25268372;
RX   PubMed=26325104;
RX   PubMed=26625219;
RX   PubMed=27894751;
CC   Population: African American.
CC   Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
DI   NCIt; C27838; Endometrial serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 29-06-23; Version: 5
//
RX   PubMed=19920829; DOI=10.1038/sj.bjc.6605448; PMCID=PMC2813756;
RA   El-Sahwi, Karim S.
RA   Bellone, Stefania
RA   Cocco, Emiliano
RA   Cargnelutti, Marilisa
RA   Casagrande, Francesca
RA   Bellone, Marta
RA   Abu-Khalaf, Maysa
RA   Buza, Natalia
RA   Tavassoli, Fattaneh A.
RA   Hui, Pei
RA   Silasi, Dan-Arin
RA   Azodi, Masoud
RA   Schwartz, Peter E.
RA   Rutherford, Thomas J.
RA   Pecorelli, Sergio
RA   Santin, Alessandro D.
RT   "In vitro activity of pertuzumab in combination with trastuzumab in
RT   uterine serous papillary adenocarcinoma.";
RL   Br. J. Cancer 102:134-143(2010).
//
RX   PubMed=21246534; DOI=10.1002/cncr.25891; PMCID=PMC3128671;
RA   Varughese, Joyce
RA   Cocco, Emiliano
RA   Bellone, Stefania
RA   de Leon, Maria
RA   Bellone, Marta
RA   Todeschini, Paola
RA   Schwartz, Peter E.
RA   Rutherford, Thomas J.
RA   Pecorelli, Sergio
RA   Santin, Alessandro D.
RT   "Uterine serous papillary carcinomas overexpress human
RT   trophoblast-cell-surface marker (Trop-2) and are highly sensitive to
RT   immunotherapy with hRS7, a humanized anti-Trop-2 monoclonal
RT   antibody.";
RL   Cancer 117:3163-3172(2011).
//
RX   PubMed=23891627; DOI=10.1016/j.ajog.2013.07.020;
RA   English, Diana P.
RA   Bellone, Stefania
RA   Cocco, Emiliano
RA   Bortolomai, Ileana
RA   Pecorelli, Sergio
RA   Lopez, Salvatore
RA   Silasi, Dan-Arin
RA   Schwartz, Peter E.
RA   Rutherford, Thomas J.
RA   Santin, Alessandro D.
RT   "Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications
RT   determine the sensitivity of uterine serous carcinoma cell lines to
RT   GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase
RT   (TORC1/2).";
RL   Am. J. Obstet. Gynecol. 209:465.e1-465.e9(2013).
//
RX   PubMed=25268372; DOI=10.1038/bjc.2014.519; PMCID=PMC4453741;
RA   Schwab, Carlton L.
RA   Bellone, Stefania
RA   English, Diana P.
RA   Roque, Dana Marie
RA   Lopez, S.
RA   Cocco, Emiliano
RA   Nicoletti, Roberta
RA   Bortolomai, Ileana
RA   Bonazzoli, Elena
RA   Ratner, Elena
RA   Silasi, Dan-Arin
RA   Azodi, Masoud
RA   Schwartz, Peter E.
RA   Rutherford, Thomas J.
RA   Santin, Alessandro D.
RT   "Afatinib demonstrates remarkable activity against HER2-amplified
RT   uterine serous endometrial cancer in vitro and in vivo.";
RL   Br. J. Cancer 111:1750-1756(2014).
//
RX   PubMed=26325104; DOI=10.1038/bjc.2015.306; PMCID=PMC4651122;
RA   Black, Jonathan D.
RA   Lopez, Salvatore
RA   Cocco, Emiliano
RA   Bellone, Stefania
RA   Altwerger, Gary
RA   Schwab, Carlton L.
RA   English, Diana P.
RA   Bonazzoli, Elena
RA   Predolini, Federica
RA   Ferrari, Francesca
RA   Ratner, Elena
RA   Silasi, Dan-Arin
RA   Azodi, Masoud
RA   Schwartz, Peter E.
RA   Santin, Alessandro D.
RT   "PIK3CA oncogenic mutations represent a major mechanism of resistance
RT   to trastuzumab in HER2/neu overexpressing uterine serous carcinomas.";
RL   Br. J. Cancer 113:1020-1026(2015).
//
RX   PubMed=26625219; DOI=10.1038/bjc.2015.388; PMCID=PMC4705897;
RA   Black, Jonathan D.
RA   Lopez, Salvatore
RA   Cocco, Emiliano
RA   Bellone, Stefania
RA   Altwerger, Gary
RA   Schwab, Carlton L.
RA   English, Diana P.
RA   Bonazzoli, Elena
RA   Predolini, Federica
RA   Ferrari, Francesca
RA   Ratner, Elena
RA   Silasi, Dan-Arin
RA   Azodi, Masoud
RA   Schwartz, Peter E.
RA   Santin, Alessandro D.
RT   "Erratum to: PIK3CA oncogenic mutations represent a major mechanism of
RT   resistance to trastuzumab in HER2/neu overexpressing uterine serous
RT   carcinomas.";
RL   Br. J. Cancer 113:1641-1641(2015).
//
RX   PubMed=27894751; DOI=10.1016/j.ygyno.2016.11.023; PMCID=PMC5183545;
RA   Bellone, Stefania
RA   Bignotti, Eliana
RA   Lonardi, Silvia
RA   Ferrari, Francesca
RA   Centritto, Floriana
RA   Masserdotti, Alice
RA   Pettinella, Francesca
RA   Black, Jonathan D.
RA   Menderes, Gulden
RA   Altwerger, Gary
RA   Hui, Pei
RA   Lopez, Salvatore
RA   de Haydu, Christopher
RA   Bonazzoli, Elena
RA   Predolini, Federica
RA   Zammataro, Luca
RA   Cocco, Emiliano
RA   Ferrari, Federico
RA   Ravaggi, Antonella
RA   Romani, Chiara
RA   Facchetti, Fabio
RA   Sartori, Enrico
RA   Odicino, Franco Edoardo
RA   Silasi, Dan-Arin
RA   Litkouhi, Babak
RA   Ratner, Elena
RA   Azodi, Masoud
RA   Schwartz, Peter E.
RA   Santin, Alessandro D.
RT   "Polymerase epsilon (POLE) ultra-mutation in uterine tumors correlates
RT   with T lymphocyte infiltration and increased resistance to
RT   platinum-based chemotherapy in vitro.";
RL   Gynecol. Oncol. 144:146-152(2017).
//