• Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=23603901).
  

PubMed=23603901; DOI=10.1101/gad.217778.113; PMCID=PMC3656328
Kui-Ming Chan, Dong Fang, Hai-Yun Gan, Rintaro Hashizume, Chuan-He Yu, Mark Schroeder, Nalin Gupta, Sabine Mueller, Charles David James, Robert Brian Jenkins, Jann Sarkaria, Zhi-Guo Zhang;
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.
Genes Dev. 27:985-990(2013)

PubMed=24305702; DOI=10.1093/neuonc/not220; PMCID=PMC3922515
Sabine Mueller, Rintaro Hashizume, Xiao-Dong Yang, Ilan Kolkowitz, Aleksandra K. Olow, Joanna J. Phillips, Ivan Smirnov, Maxwell W. Tom, Michael D. Prados, Charles David James, Mitchel Stuart Berger ...Show all 13 authors... , Nalin Gupta, Daphne Adele Haas-Kogan; Show fewer authors
Targeting Wee1 for the treatment of pediatric high-grade gliomas.
Neuro-oncol. 16:352-360(2014)

PubMed=25401693; DOI=10.1038/nm.3716; PMCID=PMC4257862
Rintaro Hashizume, Noemi Andor, Yuichiro Ihara, Robin Lerner, Hai-Yun Gan, Xiao-Yue Chen, Dong Fang, Xi Huang, Maxwell W. Tom, Vy Ngo, David A. Solomon ...Show all 18 authors... , Sabine Mueller, Pamela L. Paris, Zhi-Guo Zhang, Claudia Katharina Petritsch, Nalin Gupta, Todd A. Waldman, Charles David James; Show fewer authors
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.
Nat. Med. 20:1394-1396(2014)

PubMed=29760046; DOI=10.1158/0008-5472.CAN-17-3691; PMCID=PMC6294442
Sharmistha Pal, David Kozono, Xiao-Dong Yang, Wojciech Fendler, Whitney Fitts, Jing Ni, John A. Alberta, Jean Zhao, Kevin Xin-Ye Liu, Jie Bian, Nathalene Truffaux ...Show all 19 authors... , William Andrew Weiss, Adam C. Resnick, Pratiti Bandopadhayay, Keith Lloyd Ligon, Steven Gary DuBois, Sabine Mueller, Dipanjan Chowdhury, Daphne Adele Haas-Kogan; Show fewer authors
Dual HDAC and PI3K inhibition abrogates NFkappaB- and FOXM1-mediated DNA damage response to radiosensitize pediatric high-grade gliomas.
Cancer Res. 78:4007-4021(2018)

PubMed=34078608; DOI=10.1126/sciadv.abg4126; PMCID=PMC10166578
Juan Wang, Tina Yi-Ting Huang, Ye Hou, Elizabeth Thomas Bartom, Xin-Yan Lu, Ali Shilatifard, Feng Yue, Amanda Muhs Saratsis;
Epigenomic landscape and 3D genome structure in pediatric high-grade glioma.
Sci. Adv. 7:eabg4126.1-eabg4126.16(2021)