ID   SF8628
AC   CVCL_IT46
SY   SF-8628
DR   cancercelllines; CVCL_IT46
DR   Cosmic; 1925953
DR   GEO; GSE59366
DR   GEO; GSE59496
DR   GEO; GSM1508949
DR   GEO; GSM1508952
DR   GEO; GSM4969608
DR   GEO; GSM4969609
DR   GEO; GSM4969610
DR   GEO; GSM4969611
DR   GEO; GSM4969616
DR   GEO; GSM4969646
DR   GEO; GSM4969647
DR   GEO; GSM4969648
DR   Millipore; SCC127
DR   Wikidata; Q54952963
RX   PubMed=23603901;
RX   PubMed=24305702;
RX   PubMed=25401693;
RX   PubMed=29760046;
RX   PubMed=34078608;
CC   Sequence variation: Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=23603901).
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Genomics; ChIP-seq; H3K27me3.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
ST   Source(s): Millipore=SCC127
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 9
ST   D16S539: 9
ST   D18S51: 14
ST   D21S11: 29,30
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 10,13
ST   FGA: 19,22
ST   Penta D: 11,12
ST   Penta E: 11,13
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C94764; Diffuse intrinsic pontine glioma
DI   ORDO; Orphanet_497188; Diffuse intrinsic pontine glioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   3Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 10-04-25; Version: 15
//
RX   PubMed=23603901; DOI=10.1101/gad.217778.113; PMCID=PMC3656328;
RA   Chan K.-M., Fang D., Gan H.-Y., Hashizume R., Yu C.-H., Schroeder M.,
RA   Gupta N., Mueller S., James C.D., Jenkins R.B., Sarkaria J.,
RA   Zhang Z.-G.;
RT   "The histone H3.3K27M mutation in pediatric glioma reprograms H3K27
RT   methylation and gene expression.";
RL   Genes Dev. 27:985-990(2013).
//
RX   PubMed=24305702; DOI=10.1093/neuonc/not220; PMCID=PMC3922515;
RA   Mueller S., Hashizume R., Yang X.-D., Kolkowitz I., Olow A.K.,
RA   Phillips J.J., Smirnov I., Tom M.W., Prados M.D., James C.D.,
RA   Berger M.S., Gupta N., Haas-Kogan D.A.;
RT   "Targeting Wee1 for the treatment of pediatric high-grade gliomas.";
RL   Neuro-oncol. 16:352-360(2014).
//
RX   PubMed=25401693; DOI=10.1038/nm.3716; PMCID=PMC4257862;
RA   Hashizume R., Andor N., Ihara Y., Lerner R., Gan H.-Y., Chen X.-Y.,
RA   Fang D., Huang X., Tom M.W., Ngo V., Solomon D.A., Mueller S.,
RA   Paris P.L., Zhang Z.-G., Petritsch C.K., Gupta N., Waldman T.A.,
RA   James C.D.;
RT   "Pharmacologic inhibition of histone demethylation as a therapy for
RT   pediatric brainstem glioma.";
RL   Nat. Med. 20:1394-1396(2014).
//
RX   PubMed=29760046; DOI=10.1158/0008-5472.CAN-17-3691; PMCID=PMC6294442;
RA   Pal S., Kozono D., Yang X.-D., Fendler W., Fitts W., Ni J., Alberta J.A.,
RA   Zhao J., Liu K.X., Bian J., Truffaux N., Weiss W.A., Resnick A.C.,
RA   Bandopadhayay P., Ligon K.L., DuBois S.G., Mueller S., Chowdhury D.,
RA   Haas-Kogan D.A.;
RT   "Dual HDAC and PI3K inhibition abrogates NFkappaB- and FOXM1-mediated
RT   DNA damage response to radiosensitize pediatric high-grade gliomas.";
RL   Cancer Res. 78:4007-4021(2018).
//
RX   PubMed=34078608; DOI=10.1126/sciadv.abg4126; PMCID=PMC10166578;
RA   Wang J., Huang T.Y.-T., Hou Y., Bartom E.T., Lu X.-Y., Shilatifard A.,
RA   Yue F., Saratsis A.M.;
RT   "Epigenomic landscape and 3D genome structure in pediatric high-grade
RT   glioma.";
RL   Sci. Adv. 7:eabg4126.1-eabg4126.16(2021).
//