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Cellosaurus Bo-786-O (CVCL_IS21)

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Cell line name Bo-786-O
Accession CVCL_IS21
Resource Identification Initiative To cite this cell line use: Bo-786-O (RRID:CVCL_IS21)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-2A>G; ClinVar=VCV003148158; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1051 (786-O)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=24587095; DOI=10.1371/journal.pone.0089880; PMCID=PMC3933681
Robert L. Satcher, Tian-Hong Pan, Chien-Jui Cheng, Yu-Chen Lee, Song-Chang Lin, Guo-Yu Yu, Xiao-Xia Li, Anh G. Hoang, Pheroze Tamboli, Eric Jonasch, Gary E. Gallick, Sue-Hwa Lin;
Cadherin-11 in renal cell carcinoma bone metastasis.
PLoS ONE 9:e89880.1-e89880.10(2014)

PubMed=27993170; DOI=10.1186/s12943-016-0565-8; PMCID=PMC5168717
Klaudia Klarysa Brodaczewska, Cezary Szczylik, Michal Fiedorowicz, Camillo Porta, Anna Malgorzata Czarnecka;
Choosing the right cell line for renal cell cancer research.
Mol. Cancer 15:83.1-83.15(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IS21
Encyclopedic resources Wikidata; Q54797688
Entry history
Entry creation03-Mar-2017
Last entry update14-Aug-2025
Version number18