Cell line name |
Bo-786-O |
Accession |
CVCL_IS21 |
Resource Identification Initiative |
To cite this cell line use: Bo-786-O (RRID:CVCL_IS21) |
Comments |
Population: Caucasian. Transfected with: UniProtKB; P08659; Firefly luciferase. Transfected with: UniProtKB; P42212; GFP. Derived from site: In situ; Kidney; UBERON=UBERON_0002113. |
Sequence variations |
- Mutation; HGNC; 9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.560-2A>G; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
|
Disease |
Renal cell carcinoma (NCIt: C9385) Renal cell carcinoma (ORDO: Orphanet_217071) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_1051 (786-O) |
Sex of cell |
Male |
Age at sampling |
58Y |
Category |
Cancer cell line |
Publications | PubMed=24587095; DOI=10.1371/journal.pone.0089880 Satcher R.L., Pan T.-H., Cheng C.-J., Lee Y.-C., Lin S.-C., Yu G.-Y., Li X.-X., Hoang A.G., Tamboli P., Jonasch E., Gallick G.E., Lin S.-H. Cadherin-11 in renal cell carcinoma bone metastasis. PLoS ONE 9:E89880-E89880(2014) PubMed=27993170; DOI=10.1186/s12943-016-0565-8 Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C., Czarnecka A.M. Choosing the right cell line for renal cell cancer research. Mol. Cancer 15:83.1-83.15(2016) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_IS21
|
Encyclopedic resources |
Wikidata; Q54797688
|
Entry history |
Entry creation | 03-Mar-2017 |
Last entry update | 05-Oct-2023 |
Version number | 14 |
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