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Cellosaurus U-CH12 (CVCL_IR27)

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Cell line name U-CH12
Synonyms UCH12
Accession CVCL_IR27
Resource Identification Initiative To cite this cell line use: U-CH12 (RRID:CVCL_IR27)
Comments Doubling time: 7 days (PubMed=26183925); 11-13 days (Chordoma Foundation).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
Sequence variations
Disease Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 83Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3326; PubMed=26183925

Markers:
AmelogeninX,Y
CSF1PO11,12
D1S165613,16
D2S44111
D2S133822,23
D3S135814,19
D5S81811,12
D7S8208,12
D8S117914
D10S124814,16
D12S39119,19.3
D13S31712,13
D16S53915
D18S5117,18
D19S43312,15
D21S1127,32.2
D22S104515
FGA23,24
Penta D12
Penta E12,15
TH019.3
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; Chordoma Foundation; -; https://www.chordomafoundation.org/researchers/disease-models/u-ch12/
Publications

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
Adrian von Witzleben, Lukas T. Goerttler, Ralf Marienfeld, Holger Barth, Andre Lechel, Kevin Mellert, Michael J. Bohm, Marko Kornmann, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 15 authors... , Adrienne Margaret Flanagan, Peter Moller, Silke Bruderlein, Thomas F.E. Barth; Show fewer authors
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Daniela Jager, Thomas F.E. Barth, Silke Bruderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, Andre Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 14 authors... , Christian R. Wirtz, Peter Moller, Kevin Mellert; Show fewer authors
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032.1-2032.12(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-3326
Cell line databases/resources cancercelllines; CVCL_IR27
Encyclopedic resources Wikidata; Q54973614
Gene expression databases GEO; GSM1673859
GEO; GSM1673860
Entry history
Entry creation03-Mar-2017
Last entry update10-Apr-2025
Version number15