ID   U-CH12
AC   CVCL_IR27
SY   UCH12
DR   ATCC; CRL-3326
DR   cancercelllines; CVCL_IR27
DR   GEO; GSM1673859
DR   GEO; GSM1673860
DR   Wikidata; Q54973614
RX   PubMed=26183925;
RX   PubMed=28515451;
WW   Info; Chordoma Foundation; -; https://www.chordomafoundation.org/researchers/disease-models/u-ch12/
CC   Doubling time: 7 days (PubMed=26183925); 11-13 days (Chordoma Foundation).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=28515451).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
ST   Source(s): ATCC=CRL-3326; PubMed=26183925
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D10S1248: 14,16
ST   D12S391: 19,19.3
ST   D13S317: 12,13
ST   D16S539: 15
ST   D18S51: 17,18
ST   D19S433: 12,15
ST   D1S1656: 13,16
ST   D21S11: 27,32.2
ST   D22S1045: 15
ST   D2S1338: 22,23
ST   D2S441: 11
ST   D3S1358: 14,19
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 14
ST   FGA: 23,24
ST   Penta D: 12
ST   Penta E: 12,15
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C129927; Sacral chordoma
DI   ORDO; Orphanet_178; Chordoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   83Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 10-04-25; Version: 15
//
RX   PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270;
RA   von Witzleben A., Goerttler L.T., Marienfeld R., Barth H., Lechel A.,
RA   Mellert K., Bohm M., Kornmann M., Mayer-Steinacker R., von Baer A.,
RA   Schultheiss M., Flanagan A.M., Moller P., Bruderlein S., Barth T.F.E.;
RT   "Preclinical characterization of novel chordoma cell systems and their
RT   targeting by pharmocological inhibitors of the CDK4/6 cell-cycle
RT   pathway.";
RL   Cancer Res. 75:3823-3831(2015).
//
RX   PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709;
RA   Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B.,
RA   von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A.,
RA   Schultheiss M., Wirtz C.R., Moller P., Mellert K.;
RT   "HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and
RT   sacral chordomas.";
RL   Sci. Rep. 7:2032-2032(2017).
//