Cellosaurus cell line PC346Flu2 (CVCL

Cellosaurus PC346Flu2 (CVCL_IP23)

Cross-references
Cell line name	PC346Flu2
Accession	CVCL_IP23
Resource Identification Initiative	To cite this cell line use: PC346Flu2 (RRID:CVCL_IP23)
Comments	Characteristics: Proliferation of this cell line is androgen-independent. Selected for resistance to: ChEBI; CHEBI_5132; Flutamide. Omics: Transcriptomics; Microarray. Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations	Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (PubMed=15900601).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_4883 (PC-346C)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=15900601; DOI=10.1002/ijc.21201 Rute B. Marques, Sigrun Erkens-Schulze, Corrina M.A. de Ridder, Karin G. Hermans, Kati Waltering, Tapio Visakorpi, Jan Trapman, Johannes C. Romijn, Wytske M. van Weerden, Guido Jenster; Androgen receptor modifications in prostate cancer cells upon long-term androgen ablation and antiandrogen treatment. Int. J. Cancer 117:221-229(2005) PubMed=20976069; DOI=10.1371/journal.pone.0013500; PMCID=PMC2957443 Rute B. Marques, Natasja F. Dits, Sigrun Erkens-Schulze, Wytske M. van Weerden, Guido Jenster; Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models. PLoS ONE 5:e13500.1-e13500.16(2010)
Cell line databases/resources	cancercelllines; CVCL_IP23
Encyclopedic resources	Wikidata; Q54938579
Gene expression databases	GEO; GSM539108 GEO; GSM539109 GEO; GSM539110 GEO; GSM539111
Entry history
Entry creation	03-Mar-2017
Last entry update	10-Apr-2025
Version number	14